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Characterization and Differential Diagnosis of Postneurosurgical Meningitis

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ClinicalTrials.gov Identifier: NCT01122537
Recruitment Status : Completed
First Posted : May 13, 2010
Last Update Posted : October 1, 2013
Sponsor:
Information provided by (Responsible Party):
Sang-Ho Choi, Asan Medical Center

Brief Summary:
Meningitis is a rare complication following neurosurgical procedures and is associated with high morbidity and mortality. The aim of this study is to describe the clinical characteristics and microbiological characteristics in patients who develope meningitis following neurosurgical operations, and investigate the useful tips for the differential diagnosis of postneurosurgical meningitis.

Condition or disease
Neurosurgery

Detailed Description:
Besides description of characteristics of patients with postneurosurgical patients, we also will investigate the usefulness of prolonged cerebrospinal fluid (CSF) culture, and profiles of blood and CSF inflammatory markers for the differential diagnosis of meningitis. CSF culture will be extended upto 2 weeks. Serum procalcitonin and C-reactive protein, CSF adenosine deaminase levels will be monitored and analyzed for the differential diagnosis of meningitis.

Study Type : Observational
Actual Enrollment : 78 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Clinical Features, Microbiological Characteristics, and Differential Diagnosis of Postneurosurgical Meningitis
Study Start Date : May 2010
Primary Completion Date : September 2013
Study Completion Date : September 2013

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Meningitis
U.S. FDA Resources




Primary Outcome Measures :
  1. Development of meningitis [ Time Frame: within 4 weeks after neurosurgical operation ]

Secondary Outcome Measures :
  1. All-cause mortality [ Time Frame: within 4 weeks after the diagnosis of meningitis ]


Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
All patient who develop meningitis after neurosurgical operation
Criteria

Inclusion Criteria:

  • Cerebrospinal fluid corrected WBC >6/mm^3 and/or fever (> 38℃) and/or neck stiffness

Exclusion Criteria:

  • Patients already treated more than 48 hours for meningitis before cerebrospinal fluid examination

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01122537


Locations
Korea, Republic of
Asan Medical Center
Seoul, Korea, Republic of, 138-736
Sponsors and Collaborators
Asan Medical Center
Investigators
Principal Investigator: Sang-Ho Choi, MD Asan Medical Center

Responsible Party: Sang-Ho Choi, Doctor, Asan Medical Center
ClinicalTrials.gov Identifier: NCT01122537     History of Changes
Other Study ID Numbers: APNSM
First Posted: May 13, 2010    Key Record Dates
Last Update Posted: October 1, 2013
Last Verified: September 2013

Keywords provided by Sang-Ho Choi, Asan Medical Center:
Meningitis
infection
cerebrospinal fluid
procalcitonin
adenosine deaminase

Additional relevant MeSH terms:
Meningitis
Central Nervous System Diseases
Nervous System Diseases