Introduction of Protein S100 in Diagnostics in Minor Brain Injury Patients at Our Hospital (S100)
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|ClinicalTrials.gov Identifier: NCT01122212|
Recruitment Status : Completed
First Posted : May 13, 2010
Last Update Posted : April 21, 2015
|Condition or disease|
Severe intracerebral bleeding is still a complication even in obvious minor head injury (MHI) that makes the use of CT scanning necessary in patients with only few signs of intracerebral injury. To reduce the number of cerebral CT scans without pathologic findings measurement of protein S100 level in serum will be used in the emergency departement (ED) at our hospital.
Our hypothesis: with measurement of S100 levels cCT scans and inpatient treatment can be reduced, radiation and costs can be reduced.
From January 1st 2010 for 3-6 months all patients with head injury (all GCS) will be tested for their initial S100 level. Cut off level is set at 0,105ng/ml. During this period test results will be blinded. Decisions for further diagnostics (x-ray, cCT) and inpatient vs. outpatient treatment are made on clinical impressions as they are made now. The test results will be monitored and compared with clinical cases. Sensitivity, specificity, positive and negative predictive values will be measured.
The aim is to identify patients without risk for intracerebral bleeding (ie S100 level lower than 0,105ng/ml). Those can be managed in an outpatient way. All other patients will be diagnosed and treated as it is now.
If the test will not miss one intracranial bleeding and will save cCT scans and inpatient treatment, measurement of protein S100 will become a routine diagnostic in our ED for patients with MHI.
|Study Type :||Observational|
|Actual Enrollment :||128 participants|
|Official Title:||Introduction of Protein S100 in the Routine Diagnostics in Patients With Minor Head Injury|
|Study Start Date :||January 2010|
|Actual Primary Completion Date :||July 2010|
|Actual Study Completion Date :||January 2011|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01122212
|Münsterlingen, Thurgau, Switzerland, CH-8596|
|Principal Investigator:||Martin Blay, MD||Kantonsspital Münsterlingen|