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Fluid Resuscitation With HES 200/0.5 10% in Severe Burn Injury

This study has been completed.
Information provided by:
University of Zurich Identifier:
First received: April 28, 2010
Last updated: May 7, 2010
Last verified: May 2010
HES 200/0.5 10% is equal to ringers lactat solution.

Condition Intervention Phase
Survival Renal Failure Drug: fluid resuscitation Drug: Fluid resuscitation Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Fluid Resuscitation With HES 200/0.5 10% in Severe Burn Injury

Resource links provided by NLM:

Further study details as provided by University of Zurich:

Primary Outcome Measures:
  • Intensive care unit mortality [ Time Frame: 28 days ]
    28 days

Secondary Outcome Measures:
  • fluid amount during the first 72 hours [ Time Frame: 28 days ]
    Fluid resuscitation after burn

Enrollment: 28
Study Start Date: April 1997
Study Completion Date: March 2009
Primary Completion Date: September 1998 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: HES
Fluid resuscitation with HES
Drug: fluid resuscitation
fluid resuscitation with HES
Placebo Comparator: ringers lactat
Standard treatment
Drug: Fluid resuscitation
Fluid resuscitation in standardized fashion

Detailed Description:
30 Patients were enrolled to the study, either to the hyperoncotic HES 200/0.5 (10%) group or to the crystalloids only group. After a treatment protocol of 72 hours we collected data about complications like pulmonary failure and abdominal compartment syndrome. Furthermore, we addressed the question of incidence of mortality and renal failure.

Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • All burn victims with burned surface area bigger than 20%

Exclusion Criteria:

  • Pregnancy
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Please refer to this study by its identifier: NCT01120730

University Hospital Zurich
Zurich, Switzerland, 8091
Sponsors and Collaborators
University of Zurich
Principal Investigator: Markus Béchir, md University of Zurich
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Thomas A. Neff, Surgical ICU University Hospital Zurich Identifier: NCT01120730     History of Changes
Other Study ID Numbers: USZ-BURN
97/x ( Other Identifier: kantonale Ethikkommision )
Study First Received: April 28, 2010
Last Updated: May 7, 2010

Additional relevant MeSH terms:
Renal Insufficiency
Kidney Diseases
Urologic Diseases
Wounds and Injuries processed this record on August 16, 2017