Post Kidney Transplant Nocturnal Hypertension Prevalence and Management Study
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|ClinicalTrials.gov Identifier: NCT01120613|
Recruitment Status : Withdrawn (primary investigator left institution; not enough patients)
First Posted : May 11, 2010
Last Update Posted : May 30, 2013
|Condition or disease||Intervention/treatment||Phase|
|Hypertension||Drug: Chronotherapy||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||0 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Post Kidney Transplant Nocturnal Hypertension Prevalence and Management Study|
|Study Start Date :||April 2010|
|Estimated Primary Completion Date :||August 2010|
Patients identified with Nocturnal Hypertension, will have one of the blood pressure medications switched from daytime dosing to nighttime dosing
Patients identified with nocturnal hypertension while treated with blood pressure medications will have one medication switched from daytime to night time dosing in the following preference:
If patient is on only one daytime BP medication, it will be switched to night time dosing. No dose adjustments will be made nor any new medications will be added. Only timing of BP medication will be changed.
- Percent drop in mean SBP at night time compared to mean SBP at day time [ Time Frame: 2 months ]
- Urine Microalbumin to creatinine ratio [ Time Frame: 2 months ]
- Change in Glomerular filtration rate as measured by MDRD equation. [ Time Frame: 2 months ]Serum creatinine as a measure of kidney function will be measured at the begining and end of intervention.
- 24 hour mean systolic Blood Pressure (SBP) Control [ Time Frame: 2 months ]Ambulatory Blood pressure monitoring at the end of intervention will be used to assess 24 hour ( day and nighttime) blood pressure control We hypothesize that night time dosing of medication ( chronotherapy) will not only improve nocturnal hypertension but also improve awake blood pressure and overall 24 hour average SBP control.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01120613
|United States, New York|
|North Shore Long Island Jewish Hospital|
|Great Neck, New York, United States, 11020|
|Principal Investigator:||Rajiv Vij, MD MPH||North Shore Long Island Jewish Hospital|
|Principal Investigator:||Kenar Jhaveri, MD||North Shore Long Island Jewish Hospital|