Working... Menu

Vasodilator Free Measure of Fractional Flow Reserve (ADVISE)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01118481
Recruitment Status : Completed
First Posted : May 6, 2010
Last Update Posted : February 7, 2017
Hospital San Carlos, Madrid
Information provided by (Responsible Party):
Imperial College London

Brief Summary:
Narrowing of coronary arteries interferes with blood flow and can cause chest pain. Cardiologists sometimes quantify the extent of the narrowing by measuring the fractional flow reserve (the ratio of the pressure in the aorta to the pressure downstream of the narrowing under conditions of maximal flow). We propose a new technique based on principles of wave intensity analysis (WIA) to better assess coronary stenosis and the significance of the narrowing without the need for administration of vasodilator agents such as adenosine. This would simplify assessment and improve our ability to advise patients whether stent treatment will help their symptoms.

Condition or disease
Coronary Stenosis

Layout table for study information
Study Type : Observational
Actual Enrollment : 157 participants
Observational Model: Other
Time Perspective: Prospective
Official Title: ADenosine Vasodilator Independent Stenosis Evaluation Study (ADVISE)
Study Start Date : January 2010
Actual Primary Completion Date : June 2011
Actual Study Completion Date : June 2011

Pressure and flow velocity
Pressure only

Primary Outcome Measures :
  1. Correlation and descriptive characteristics between adenosine free measure of stenosis severity and FFR [ Time Frame: Study end ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with coronary stenosis without exclusion criteria

Inclusion Criteria:

  • Patients with coronary stenosis

Exclusion Criteria:

  • Patient's with cardiac pacemakers, valvular heart disease, and chronic renal failure
  • Unable to consent
  • Contraindications to adenosine
  • Contraindications to cardiac MRI

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01118481

Layout table for location information
United Kingdom
Imperial College NHS Trust
London, United Kingdom
Sponsors and Collaborators
Imperial College London
Hospital San Carlos, Madrid
Layout table for investigator information
Principal Investigator: Justin E Davies, BSc, MBBS, MRCP, PhD Imperial College London

Publications automatically indexed to this study by Identifier (NCT Number):
Layout table for additonal information
Responsible Party: Imperial College London Identifier: NCT01118481     History of Changes
Other Study ID Numbers: 1428
First Posted: May 6, 2010    Key Record Dates
Last Update Posted: February 7, 2017
Last Verified: February 2017

Keywords provided by Imperial College London:
Coronary stenosis
Wave intensity analysis
Instantaneous Flow Reserve
Fractional Flow Reserve

Additional relevant MeSH terms:
Layout table for MeSH terms
Constriction, Pathologic
Coronary Stenosis
Pathological Conditions, Anatomical
Coronary Disease
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Vasodilator Agents