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Systematic Assessment of Competitive Flow in Coronary Artery Bypass Grafts by Wave Intensity Analysis

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified July 2011 by Imperial College London.
Recruitment status was:  Recruiting
Information provided by:
Imperial College London Identifier:
First received: May 5, 2010
Last updated: July 28, 2011
Last verified: July 2011
Narrowing of the arteries that supply blood to the heart can lead to heart attacks and death. One way of treating this is to use artery and vein grafts from other parts of the body to bypass the narrowing. However, the blood flow from these grafts "competes" with flow through the natural coronary artery. This may contribute to grafts narrowing with time. This protocol aims to determine the pressure changes responsible for this effect. This could improve our understanding of why some grafts last longer than others.

Coronary Artery Bypass

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Systematic Assessment of Competitive Flow in Coronary Artery Bypass Grafts by Wave Intensity Analysis

Resource links provided by NLM:

Further study details as provided by Imperial College London:

Estimated Enrollment: 40
Study Start Date: January 2010

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Genders Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with previous bypass grafts undergoing angiography/ angioplasty who meet stduy criteria

Inclusion Criteria:

  • Patients with previous coronary artery bypass grafts undergoing coronary angiography and graft restudy

Exclusion Criteria:

  • Patient's with cardiac pacemakers, valvular heart disease, and chronic renal failure
  • Unable to consent
  • Contraindications to adenosine
  • Contraindications to cardiac MRI
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01118468

United Kingdom
Imperial College NHS Trust
London, United Kingdom
Sponsors and Collaborators
Imperial College London
Principal Investigator: Justin E Davies, MRCP PhD Imperial College London
  More Information

Responsible Party: Dr Justin E Davies, Imperial College London Identifier: NCT01118468     History of Changes
Other Study ID Numbers: 1426 
Study First Received: May 5, 2010
Last Updated: July 28, 2011
Health Authority: United Kingdom: Research Ethics Committee

Keywords provided by Imperial College London:
Competitive Flow
Coronary artery bypass
Wave Intensity Analysis processed this record on January 14, 2017