Comment Period Extended to 3/23/2015 for Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials
Trial record 1 of 181 for:    Open Studies | "Coronary Artery Bypass"
Previous Study | Return to List | Next Study

Systematic Assessment of Competitive Flow in Coronary Artery Bypass Grafts by Wave Intensity Analysis

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2011 by Imperial College London.
Recruitment status was  Recruiting
Information provided by:
Imperial College London Identifier:
First received: May 5, 2010
Last updated: July 28, 2011
Last verified: July 2011

Narrowing of the arteries that supply blood to the heart can lead to heart attacks and death. One way of treating this is to use artery and vein grafts from other parts of the body to bypass the narrowing. However, the blood flow from these grafts "competes" with flow through the natural coronary artery. This may contribute to grafts narrowing with time. This protocol aims to determine the pressure changes responsible for this effect. This could improve our understanding of why some grafts last longer than others.

Coronary Artery Bypass

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Systematic Assessment of Competitive Flow in Coronary Artery Bypass Grafts by Wave Intensity Analysis

Resource links provided by NLM:

Further study details as provided by Imperial College London:

Estimated Enrollment: 40
Study Start Date: January 2010

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients with previous bypass grafts undergoing angiography/ angioplasty who meet stduy criteria


Inclusion Criteria:

  • Patients with previous coronary artery bypass grafts undergoing coronary angiography and graft restudy

Exclusion Criteria:

  • Patient's with cardiac pacemakers, valvular heart disease, and chronic renal failure
  • Unable to consent
  • Contraindications to adenosine
  • Contraindications to cardiac MRI
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01118468

Contact: Justin E Davies, MRCP, PhD 020 7594 33 86
Contact: Sayan Sen, MRCP 020 7594 33 86

United Kingdom
Imperial College NHS Trust Recruiting
London, United Kingdom
Contact: Justin E Davies, MRCP, PhD    020 7594 33 86   
Contact: Sayan Sen    020 7594 33 86   
Sponsors and Collaborators
Imperial College London
Principal Investigator: Justin E Davies, MRCP PhD Imperial College London
  More Information

No publications provided

Responsible Party: Dr Justin E Davies, Imperial College London Identifier: NCT01118468     History of Changes
Other Study ID Numbers: 1426
Study First Received: May 5, 2010
Last Updated: July 28, 2011
Health Authority: United Kingdom: Research Ethics Committee

Keywords provided by Imperial College London:
Competitive Flow
Coronary artery bypass
Wave Intensity Analysis processed this record on March 03, 2015