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Systematic Assessment of Competitive Flow in Coronary Artery Bypass Grafts by Wave Intensity Analysis

This study is currently recruiting participants. (see Contacts and Locations)
Verified February 2017 by Imperial College London
Information provided by (Responsible Party):
Imperial College London Identifier:
First received: May 5, 2010
Last updated: February 6, 2017
Last verified: February 2017
Narrowing of the arteries that supply blood to the heart can lead to heart attacks and death. One way of treating this is to use artery and vein grafts from other parts of the body to bypass the narrowing. However, the blood flow from these grafts "competes" with flow through the natural coronary artery. This may contribute to grafts narrowing with time. This protocol aims to determine the pressure changes responsible for this effect. This could improve our understanding of why some grafts last longer than others.

Coronary Artery Bypass

Study Type: Observational
Study Design: Observational Model: Other
Time Perspective: Prospective
Official Title: Systematic Assessment of Competitive Flow in Coronary Artery Bypass Grafts by Wave Intensity Analysis

Resource links provided by NLM:

Further study details as provided by Imperial College London:

Estimated Enrollment: 40
Study Start Date: January 2010
Estimated Study Completion Date: December 2019
Estimated Primary Completion Date: December 2019 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with previous bypass grafts undergoing angiography/ angioplasty who meet stduy criteria

Inclusion Criteria:

  • Patients with previous coronary artery bypass grafts undergoing coronary angiography and graft restudy

Exclusion Criteria:

  • Patient's with cardiac pacemakers, valvular heart disease, and chronic renal failure
  • Unable to consent
  • Contraindications to adenosine
  • Contraindications to cardiac MRI
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01118468

Contact: Justin E Davies, MRCP, PhD 020 7594 33 86
Contact: Sayan Sen, MRCP 020 7594 33 86

United Kingdom
Imperial College NHS Trust Recruiting
London, United Kingdom
Contact: Justin E Davies, MRCP, PhD    020 7594 33 86   
Contact: Sayan Sen    020 7594 33 86   
Sponsors and Collaborators
Imperial College London
Principal Investigator: Justin E Davies, MRCP PhD Imperial College London
  More Information

Responsible Party: Imperial College London Identifier: NCT01118468     History of Changes
Other Study ID Numbers: 1426
Study First Received: May 5, 2010
Last Updated: February 6, 2017

Keywords provided by Imperial College London:
Competitive Flow
Coronary artery bypass
Wave Intensity Analysis processed this record on May 25, 2017