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Systematic Assessment of Competitive Flow in Coronary Artery Bypass Grafts by Wave Intensity Analysis

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ClinicalTrials.gov Identifier: NCT01118468
Recruitment Status : Recruiting
First Posted : May 6, 2010
Last Update Posted : February 8, 2017
Sponsor:
Information provided by (Responsible Party):
Imperial College London

Brief Summary:
Narrowing of the arteries that supply blood to the heart can lead to heart attacks and death. One way of treating this is to use artery and vein grafts from other parts of the body to bypass the narrowing. However, the blood flow from these grafts "competes" with flow through the natural coronary artery. This may contribute to grafts narrowing with time. This protocol aims to determine the pressure changes responsible for this effect. This could improve our understanding of why some grafts last longer than others.

Condition or disease
Coronary Artery Bypass

Study Type : Observational
Estimated Enrollment : 40 participants
Observational Model: Other
Time Perspective: Prospective
Official Title: Systematic Assessment of Competitive Flow in Coronary Artery Bypass Grafts by Wave Intensity Analysis
Study Start Date : January 2010
Estimated Primary Completion Date : December 2019
Estimated Study Completion Date : December 2019

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with previous bypass grafts undergoing angiography/ angioplasty who meet stduy criteria
Criteria

Inclusion Criteria:

  • Patients with previous coronary artery bypass grafts undergoing coronary angiography and graft restudy

Exclusion Criteria:

  • Patient's with cardiac pacemakers, valvular heart disease, and chronic renal failure
  • Unable to consent
  • Contraindications to adenosine
  • Contraindications to cardiac MRI

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01118468


Contacts
Contact: Justin E Davies, MRCP, PhD 020 7594 33 86 justin.davies@imperial.ac.uk
Contact: Sayan Sen, MRCP 020 7594 33 86 sayan.sen@imperial.ac.uk

Locations
United Kingdom
Imperial College NHS Trust Recruiting
London, United Kingdom
Contact: Justin E Davies, MRCP, PhD    020 7594 33 86    justin.davies@imperial.ac.uk   
Contact: Sayan Sen    020 7594 33 86    sayan.sen@imperial.ac.uk   
Sponsors and Collaborators
Imperial College London
Investigators
Principal Investigator: Justin E Davies, MRCP PhD Imperial College London

Responsible Party: Imperial College London
ClinicalTrials.gov Identifier: NCT01118468     History of Changes
Other Study ID Numbers: 1426
First Posted: May 6, 2010    Key Record Dates
Last Update Posted: February 8, 2017
Last Verified: February 2017

Keywords provided by Imperial College London:
Competitive Flow
Coronary artery bypass
Wave Intensity Analysis