Determination of the Acute Effects of Aortic Stenosis on Coronary Artery Haemodynamics

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2010 by Imperial College London.
Recruitment status was:  Recruiting
Information provided by:
Imperial College London Identifier:
First received: May 5, 2010
Last updated: NA
Last verified: May 2010
History: No changes posted
Narrowing of the main valve which controls blood leaving the heart leads to a marked increase in death. To overcome this narrowing the heart muscle thickens abnormally and contracts more vigorously. However, in doing so, blood flow patterns to the heart muscle change through mechanisms which are incompletely understood. New technology allows such heart valve blockages to be fixed using balloons and metal stents inserted through tubes placed in arteries in the leg. Using sensors placed in these tubes it is possible to make detailed measurements of coronary flow and pressure, and apply new mathematical techniques to allow a better understanding of the detrimental effects that aortic stenosis has on coronary flow, before and after valve surgery.

Aortic Valve Stenosis

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Determination of the Acute Effects of Aortic Stenosis on Coronary Artery Haemodynamics

Resource links provided by NLM:

Further study details as provided by Imperial College London:

Biospecimen Retention:   Samples With DNA
Myocardial biopsy specimens

Estimated Enrollment: 6
Study Start Date: December 2009

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients undergoing transcutaneous aortic valve insertion who meet study criteria

Inclusion Criteria:

  • Severe Aortic Stenosis undergoing TAVI
  • Normal coronary arteries
  • Normal left ventricular function
  • No other valvular pathology

Exclusion Criteria:

  • Unable to consent
  • Left ventricular impairment
  • Left ventricular regional wall motion abnormality
  • Other valve abnormality
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01118442

United Kingdom
Imperial College NHS Trust
London, United Kingdom
Sponsors and Collaborators
Imperial College London
Principal Investigator: Justin E Davies, MRCP PhD Imperial College London
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Dr Justin E Davies, Imperial College London Identifier: NCT01118442     History of Changes
Other Study ID Numbers: 1424 
Study First Received: May 5, 2010
Last Updated: May 5, 2010

Keywords provided by Imperial College London:
Aortic Stenosis
Coronary Flow
Wave Intensity Analysis

Additional relevant MeSH terms:
Constriction, Pathologic
Aortic Valve Stenosis
Pathological Conditions, Anatomical
Heart Valve Diseases
Heart Diseases
Cardiovascular Diseases
Ventricular Outflow Obstruction processed this record on January 19, 2017