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The Immune Tolerance Mechanism Induced by IL-17-producing Regulatory T Cells in the Orthotopic Liver Transplant Recipients With Aspergillosis

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2010 by Shanghai Jiao Tong University School of Medicine.
Recruitment status was:  Enrolling by invitation
Information provided by:
Shanghai Jiao Tong University School of Medicine Identifier:
First received: May 4, 2010
Last updated: NA
Last verified: May 2010
History: No changes posted
Infection accounted for the first cause of death in patients after liver transplantation, and 2 / 3 of the cause of death was fungal infections. The investigators group early found that T cell subsets playing a role of inducing immune tolerance were significantly increased in vivo of liver transplantation patients with aspergillus infection, which may be a kind of Treg cells expressing IL-17. To explore the immune tolerance mechanism induced by the immune balance cells is important to liver transplantation patients for improving efficacy and reducing the mortality. Therefore, the investigators are going to get the blood sample and liver tissue of the liver transplantation patients before and after treatment of aspergillus infection, flow cytometry analysis of blood T cell subsets, Cytometric Bead Array to detect changes in blood cytokines, laser capture microdissection to obtain liver biopsies of inflammatory cells in portal area and further for analysis of T cell subsets and protein. And the investigators are also to investigate the characteristics of CCR6 + CD4 + FOXP3 + Treg cell clones secreting IL-17 and the capacity of which suppressing conventional T cell proliferation. This study may find new methods, such as certain types of T cell subsets or cytokines for the treatment of liver transplant patients, which not only to anti-rejection but also to reduce fungal infection.

Liver Transplantation Aspergillus Interleukin-17 Treg Cell Immune Tolerance

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by Shanghai Jiao Tong University School of Medicine:

Enrollment: 50
Study Start Date: May 2010

Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
liver transplantation patients with aspergillus infection or without aspergillus infection

Inclusion Criteria:

Liver transplantation patients

Exclusion Criteria:


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No Contacts or Locations Provided
  More Information

Responsible Party: Shanghai First People's Hospital Identifier: NCT01117077     History of Changes
Other Study ID Numbers: 10ZR1423900
Study First Received: May 4, 2010
Last Updated: May 4, 2010

Keywords provided by Shanghai Jiao Tong University School of Medicine:
liver transplantation
aspergillus infection
Treg cell
immune tolerance processed this record on September 21, 2017