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Local Effects of Epinephrine on Lactate, Glucose, Lipid and Protein Metabolism in Bilaterally Perfused Human Legs

This study has been completed.
Information provided by (Responsible Party):
University of Aarhus Identifier:
First received: April 9, 2010
Last updated: November 4, 2011
Last verified: November 2011
The purpose of this study is to define the local metabolic effects of epinephrine in the bilaterally perfused human leg.

Condition Intervention
Drug: Epinephrine

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single Blind (Participant)
Primary Purpose: Basic Science
Official Title: Local Effects of Epinephrine on Lactate, Glucose, Lipid and Protein Metabolism in Bilaterally Perfused Human Legs

Resource links provided by NLM:

Further study details as provided by University of Aarhus:

Primary Outcome Measures:
  • Arterio-Venous balances of metabolites [ Time Frame: 6 hours infusion ]
    Acute regional effect of epinephrine infusion in the femoral artery

Enrollment: 10
Study Start Date: October 2004
Study Completion Date: January 2010
Primary Completion Date: November 2009 (Final data collection date for primary outcome measure)
Intervention Details:
    Drug: Epinephrine
    unilateral leg infusion of Epinephrine 0.4 micrograms/m2/min
    Other Name: Adrenaline

Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Male

Exclusion Criteria:

  • Comorbidity
  • Females
  Contacts and Locations
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Please refer to this study by its identifier: NCT01116609

Medical research laboratories, Aarhus University Hospital
Aarhus, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
Principal Investigator: Niels Moller, Professor Medical Research Laboratories, Aarhus University, Denmark
  More Information

Responsible Party: University of Aarhus Identifier: NCT01116609     History of Changes
Other Study ID Numbers: Epi-perfusion
Study First Received: April 9, 2010
Last Updated: November 4, 2011

Keywords provided by University of Aarhus:
Effects of epinephrine in healthy volunteers

Additional relevant MeSH terms:
Epinephryl borate
Adrenergic alpha-Agonists
Adrenergic Agonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Adrenergic beta-Agonists
Bronchodilator Agents
Autonomic Agents
Peripheral Nervous System Agents
Anti-Asthmatic Agents
Respiratory System Agents
Vasoconstrictor Agents processed this record on April 28, 2017