Local Effects of Epinephrine on Lactate, Glucose, Lipid and Protein Metabolism in Bilaterally Perfused Human Legs

This study has been completed.
Information provided by (Responsible Party):
University of Aarhus
ClinicalTrials.gov Identifier:
First received: April 9, 2010
Last updated: November 4, 2011
Last verified: November 2011
The purpose of this study is to define the local metabolic effects of epinephrine in the bilaterally perfused human leg.

Condition Intervention
Drug: Epinephrine

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
Official Title: Local Effects of Epinephrine on Lactate, Glucose, Lipid and Protein Metabolism in Bilaterally Perfused Human Legs

Resource links provided by NLM:

Further study details as provided by University of Aarhus:

Primary Outcome Measures:
  • Arterio-Venous balances of metabolites [ Time Frame: 6 hours infusion ] [ Designated as safety issue: No ]
    Acute regional effect of epinephrine infusion in the femoral artery

Enrollment: 10
Study Start Date: October 2004
Study Completion Date: January 2010
Primary Completion Date: November 2009 (Final data collection date for primary outcome measure)
Intervention Details:
    Drug: Epinephrine
    unilateral leg infusion of Epinephrine 0.4 micrograms/m2/min
    Other Name: Adrenaline

Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Male

Exclusion Criteria:

  • Comorbidity
  • Females
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01116609

Medical research laboratories, Aarhus University Hospital
Aarhus, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
Principal Investigator: Niels Moller, Professor Medical Research Laboratories, Aarhus University, Denmark
  More Information

No publications provided

Responsible Party: University of Aarhus
ClinicalTrials.gov Identifier: NCT01116609     History of Changes
Other Study ID Numbers: Epi-perfusion
Study First Received: April 9, 2010
Last Updated: November 4, 2011
Health Authority: Denmark: The Regional Committee on Biomedical Research Ethics

Keywords provided by University of Aarhus:
Effects of epinephrine in healthy volunteers

Additional relevant MeSH terms:
Epinephryl borate
Adrenergic Agents
Adrenergic Agonists
Adrenergic alpha-Agonists
Adrenergic beta-Agonists
Anti-Asthmatic Agents
Autonomic Agents
Bronchodilator Agents
Cardiovascular Agents
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Peripheral Nervous System Agents
Pharmacologic Actions
Physiological Effects of Drugs
Respiratory System Agents
Therapeutic Uses
Vasoconstrictor Agents

ClinicalTrials.gov processed this record on November 24, 2015