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Local Effects of Epinephrine on Lactate, Glucose, Lipid and Protein Metabolism in Bilaterally Perfused Human Legs

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01116609
First Posted: May 5, 2010
Last Update Posted: November 7, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
University of Aarhus
  Purpose
The purpose of this study is to define the local metabolic effects of epinephrine in the bilaterally perfused human leg.

Condition Intervention
Healthy Drug: Epinephrine

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: Local Effects of Epinephrine on Lactate, Glucose, Lipid and Protein Metabolism in Bilaterally Perfused Human Legs

Resource links provided by NLM:


Further study details as provided by University of Aarhus:

Primary Outcome Measures:
  • Arterio-Venous balances of metabolites [ Time Frame: 6 hours infusion ]
    Acute regional effect of epinephrine infusion in the femoral artery


Enrollment: 10
Study Start Date: October 2004
Study Completion Date: January 2010
Primary Completion Date: November 2009 (Final data collection date for primary outcome measure)
Intervention Details:
    Drug: Epinephrine
    unilateral leg infusion of Epinephrine 0.4 micrograms/m2/min
    Other Name: Adrenaline
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Male

Exclusion Criteria:

  • Comorbidity
  • Females
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01116609


Locations
Denmark
Medical research laboratories, Aarhus University Hospital
Aarhus, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
Investigators
Principal Investigator: Niels Moller, Professor Medical Research Laboratories, Aarhus University, Denmark
  More Information

Responsible Party: University of Aarhus
ClinicalTrials.gov Identifier: NCT01116609     History of Changes
Other Study ID Numbers: Epi-perfusion
First Submitted: April 9, 2010
First Posted: May 5, 2010
Last Update Posted: November 7, 2011
Last Verified: November 2011

Keywords provided by University of Aarhus:
Phenylalanine
Palmitate
hyperinsulinemic-euglycemic-clamp
Effects of epinephrine in healthy volunteers

Additional relevant MeSH terms:
Epinephrine
Racepinephrine
Epinephryl borate
Adrenergic alpha-Agonists
Adrenergic Agonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Adrenergic beta-Agonists
Bronchodilator Agents
Autonomic Agents
Peripheral Nervous System Agents
Anti-Asthmatic Agents
Respiratory System Agents
Mydriatics
Sympathomimetics
Vasoconstrictor Agents