Inhibitors of Angiotensin II in Proteinuric Mesangioproliferative Glomerulonephritis
|ClinicalTrials.gov Identifier: NCT01115426|
Recruitment Status : Completed
First Posted : May 4, 2010
Last Update Posted : May 4, 2010
|Condition or disease||Intervention/treatment||Phase|
|IGA Glomerulonephritis||Drug: Ramipril or losartan||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||20 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Long-term Treatment by Inhibitors of Angiotensin II at Low Doses in Non-nephrotic Proteinuric Patients With Pauciimmune and IgA Mesangioproliferative Glomerulonephritis|
|Study Start Date :||January 1997|
|Actual Primary Completion Date :||January 2007|
|Actual Study Completion Date :||January 2008|
anti-angiotensin II drugs
Never treated patients with non-nephrotic proteinuria (1-3 g/day), microhematuria, no-evidence of renal failure or other relevant diseases and with diagnosis of I-II stage IgA- or pauciimmune-MsPGN were considered eligible.
Drug: Ramipril or losartan
Ramipril (5 mg/day) was started soon after the enrollment and continued throughout the follow-up, having Losartan (50 mg/day) as alternative.
Other Name: renin-angiotensin system (RAS) inhibitors
- renal function and proteinuria [ Time Frame: at the end of first year of observation ]
In particular, the end points of the study were a loss >20% of basal GFR and a decrease of basal daily proteinuria < 20% at the end of first year of observation.
GFR was calculated using both the abbreviated Modification of Diet in Renal Disease (MDRD) study equation and measured creatinine clearance. For each patient, a time-averaged (TA) proteinuria were calculated as an average of the mean of every-6month period's 24-hour proteinuria measurements.
- serum levels of creatinine [ Time Frame: at the end of first years of observation ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01115426
|"Mater Domini" Hospital|
|Catanzaro, Calabria, Italy, 88100|
|Study Chair:||Giorgio Fuiano, Professor||"Magna Graecia" University of Catanzaro, Nephrology Unit|