Pilot Study of RNA as a Biomarker for Autosomal Dominant Polycystic Kidney Disease
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01114594|
Recruitment Status : Completed
First Posted : May 3, 2010
Last Update Posted : August 10, 2012
|Condition or disease|
|Chronic Kidney Disease Polycystic Kidney, Autosomal Dominant|
Proteins and small molecules in urine (biomarkers) have been used to probe for kidney and systemic diseases for hundreds of years. Urine reportedly contains a type of molecule called microRNA (miRNAs) that regulate a large number of biological processes. Impaired function of miRNAs is now recognized in an increasing number of disease processes. In the search for new biomarkers, the regulatory function of miRNAs and the relative simplicity and precision of characterizing miRNAs, are potential advantages when compared to traditional biomarkers.
The aim of this pilot project is to assess the potential of urine miRNAs as biomarkers for characterizing patients with autosomal dominant polycystic kidney disease (ADPKD), the most prevalent inherited cause of kidney failure. Individuals with other causes of chronic kidney disease (e.g., diabetes, glomerulonephritis), who are matched for key characteristics (e.g. age, sex, level of kidney function) will serve as the control population. A technique for isolation of miRNAs from urine samples will be tailored for the specific needs of this project. Biochemical and computational analysis of small RNAs from these samples will provide urine miRNA profiles and key variability statistics that will be use to design follow-up projects involving patients with kidney disease.
|Study Type :||Observational|
|Actual Enrollment :||42 participants|
|Official Title:||Pilot Study of RNA as a Biomarker for Autosomal Dominant Polycystic Kidney Disease|
|Study Start Date :||April 2010|
|Primary Completion Date :||April 2012|
|Study Completion Date :||April 2012|
Patients with Autosomal Dominant Polycystic Kidney Disease
Patients with non-Polycystic Chronic Kidney Disease
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01114594
|United States, New York|
|The Rogosin Institute|
|New York, New York, United States, 10021|
|Principal Investigator:||Jon Blumenfeld, MD||The Rogosin Institute|