Biomarkers for Prognosis of Ambulatory Chronic Heart Failure Patients
Biomarkers representing distinct biological domains including neurohormonal, inflammatory, metabolic-nutritional, oxidative-nitrosative and myocardial injury, might alone or in combination provide prognostic information on mortality in heart failure patients with preserved or impaired systolic function.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Circulating Biomarkers as Prognostic Indicators of Death in Ambulatory Heart Failure Patients|
|Study Start Date:||October 1998|
|Study Completion Date:||January 2009|
|Primary Completion Date:||May 2003 (Final data collection date for primary outcome measure)|
Upon enrollment in the study, Troponin I (cTn I), BNP, norepinephrine, plasma renin activity, aldosterone, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), soluble receptor of interleukin 2 (sIL-2R), leptin, prealbumin, free malondialdehyde, 15-F2t-isoprostane and protein-bound nitrotyrosine were measured in stable ambulatory, non diabetic, elderly heart failure patients. Patients were followed up until death or study termination (31st January 2009).
Please refer to this study by its ClinicalTrials.gov identifier: NCT01113866
|Università di Parma|
|Parma, Italy, 43126|
|Principal Investigator:||Aderville Cabassi, MD||University of Parma|