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Daily Monitoring of Exhaled Nitric Oxide in Asthmatic Patients

This study has been completed.
Azienda Ospedaliera Universitaria Policlinico
Information provided by:
Universita di Verona Identifier:
First received: April 28, 2010
Last updated: April 30, 2010
Last verified: January 2007

Previous studies have demonstrated that exhaled nitric oxide can be useful to monitor the efficacy of anti-inflammatory treatment as well as to predict a risk of asthma relapse in asthmatic patients.

The aim of the present study is to evaluate the time course of exhaled nitric oxide in mild asthmatic patients, stopping regular treatment with inhaled corticosteroids, if it is possible, in relationship with symptoms and lung function.


Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Daily Monitoring of Exhaled Nitric Oxide in Asthmatic Patients Stopping Anti-inflammatory Treatment

Resource links provided by NLM:

Further study details as provided by Universita di Verona:

Enrollment: 40
Study Start Date: January 2007
Study Completion Date: January 2010
Detailed Description:
All patients were evaluated with pulmonary lung function, exhaled nitric oxide and peak expiratory flow (PEF) and fill in a personal diary for the first two weeks when patients are in treatment; the same evaluation will be made for other four weeks without treatment.

Ages Eligible for Study:   5 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
children with asthma visited in the outpatients clinic at University of Verona were invited to participate to the study

Inclusion Criteria:

  • mild asthmatic treated with low dose inhaled steroids for whom it has to be considered stop of steroid treatment according to GINA guidelines

Exclusion Criteria:

  • age < 5 years
  • chronic respiratory diseases
  Contacts and Locations
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Please refer to this study by its identifier: NCT01113853

Pediatric Department University of Verona
Verona, Italy, 37100
Sponsors and Collaborators
Universita di Verona
Azienda Ospedaliera Universitaria Policlinico
Principal Investigator: Giorgio L Piacentini, MD Universita di Verona
  More Information

Responsible Party: attilio L Boner, Università di Verona Identifier: NCT01113853     History of Changes
Other Study ID Numbers: AOV 1360
Study First Received: April 28, 2010
Last Updated: April 30, 2010

Keywords provided by Universita di Verona:
exhaled nitric oxide
lung function

Additional relevant MeSH terms:
Nitric Oxide
Bronchodilator Agents
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Asthmatic Agents
Respiratory System Agents
Free Radical Scavengers
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Endothelium-Dependent Relaxing Factors
Vasodilator Agents
Protective Agents processed this record on September 21, 2017