The Link Between Human Cytomegalovirus (HCMV) and Hypertension

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01113359
Recruitment Status : Unknown
Verified April 2010 by Beijing Chao Yang Hospital.
Recruitment status was:  Recruiting
First Posted : April 29, 2010
Last Update Posted : April 29, 2010
Information provided by:
Beijing Chao Yang Hospital

Brief Summary:

It has been reported that mouse cytomegalovirus infection alone can elevate the blood pressure in mice. Since HCMV has uniquely evolved with its human host, with little genetic similarity to the animal CMV counterparts, and it only replicates in human, an epidemiological study is required to define the relevance of HCMV infection and expression of hcmv-miRNA-UL112 to the pathogenesis of essential hypertension.

The investigators found that hcmv-miR-UL112, a human cytomegalovirus (HCMV)-encoded miRNA, was highly expressed in the hypertensive patients. Among the top miRNA target predictions, the investigators demonstrate that IRF-1 is a direct target gene of hcmv-miR-UL112, along with MICB that has been previously reported. Both IRF-1 and MICB play critical roles in immuno/inflammatory and anti-infection response. Thus, the investigators speculated that IRF-1 and MICB repression by hcmv-miR-UL112 could be considered a unifying mechanism that evades the host response at several levels: antiviral, inflammatory, and immune. In addition, there is an increasing evidence that IRF-1 may be important in apoptosis, angiogenesis, neointima formation and the pathogenesis of vascular diseases. IRF-1 can up-regulate angiotensin II type 2 receptor (AGTR2) that exerts antiproliferative and proapoptotic actions and affects regulation of blood pressure. It has been reported that the targeted disruption of the mouse AGTR2 gene resulted in a significant increase in blood pressure and increased sensitivity to angiotensin II. The nitric oxide synthase expression and NO synthesis in macrophages and distinct cardiomyocytes are induced and controlled by IRF-1 in response to inflammation, important steps in vascular biology that may improve endothelial function and inhibit smooth muscle cell migration, and a key pathophysiological event in hypertension. Collectively, these reports support a strong relationship between IRF-1 regulation and hypertension, indicating a potential role of hcmv-miR-UL112 and HCMV infection in the pathogenesis of hypertension.Thus, the investigators want to investigate the potential link between HCMV infection and essential hypertension.

Condition or disease
HCMV Infection Hypertension

Study Type : Observational
Estimated Enrollment : 300 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: The Potential Link Between HCMV Infection and Essential Hypertension
Study Start Date : April 2010
Estimated Primary Completion Date : May 2010
Estimated Study Completion Date : May 2010

Resource links provided by the National Library of Medicine

study group
hypertensive patients
control group
healthy volunteer

Primary Outcome Measures :
  1. The positive rate of HCMV infection in hypertensive patients and healthy control [ Time Frame: 1 month ]

Secondary Outcome Measures :
  1. HCMV copies number per ml plasma of hypertensive patients and healthy controls [ Time Frame: 1 month ]

Biospecimen Retention:   Samples Without DNA

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   30 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
essential hypertensive patients:

Inclusion Criteria:

  • Patients with essential hypertension are assessed for potential secondary causes, for the severity of hypertension, other risk factors and for end-organ damage
  • Aged between 30 to 60 years
  • Untreated (whole day average > 140/90 mmHg) or treated hypertension whole-day average < 140/85), as determined by 24-hour blood pressure monitoring.

Exclusion Criteria:

  • Cancer
  • Diabetes
  • Smoking
  • Renal failure
  • Stroke
  • Peripheral artery disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01113359

China, Chaoyang
Jun Cai Recruiting
Beijing, Chaoyang, China, 100020
Contact: Jun Cai, MD    +86 10 85231217   
Sub-Investigator: Jun Cai, MD         
Sponsors and Collaborators
Beijing Chao Yang Hospital
Principal Investigator: Xin-Chun Yang, MD Beijing Chao Yang Hospital

Responsible Party: Jun Cai / Heart Center, Beijing Chao Yang Hospital Identifier: NCT01113359     History of Changes
Other Study ID Numbers: BJCY-CV-2010001
YXinchun ( Registry Identifier: YXinchun )
First Posted: April 29, 2010    Key Record Dates
Last Update Posted: April 29, 2010
Last Verified: April 2010

Keywords provided by Beijing Chao Yang Hospital:
HCMV infection
The Potential Link Between HCMV Infection and Essential Hypertension

Additional relevant MeSH terms:
Communicable Diseases
Cytomegalovirus Infections
Vascular Diseases
Cardiovascular Diseases
Herpesviridae Infections
DNA Virus Infections
Virus Diseases