NETs Formation in Patients With Recurrent Pyogenic Infections (NETS) (NETs)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01112592|
Recruitment Status : Unknown
Verified March 2012 by Meir Medical Center.
Recruitment status was: Recruiting
First Posted : April 28, 2010
Last Update Posted : February 27, 2013
|Condition or disease|
Our laboratory at Meir Medical Center, Kfar Saba, is the country's main center for neutrophil function, and serves about 80% of Israel's population. Patients are referred subsequent to recurrent, persistent, or unusual infections and after completing preliminary screening of the immune system and ruling out a humoral, cellular or complement immune deficiency. Initial workup includes chemotaxis, superoxide production (SOP), and bactericidal activity (BA). Based on test findings, further evaluation for a qualitative phagocytic disorder is conducted. Overall, impairment of phagocytic activity is found in about 33% (impaired chemotaxis in 16%, SOP in 6%, and BA in 24%). In the other 67%, no impairment of the immune function is found that can explain their tendency for recurrent pyogenic infections.
In 2004 a novel function of the neutrophil was identified: formation of neutrophil extracellular traps (NETs). Apparently, neutrophils are able to extrude part of their cellular contents in the form of DNA, histones and proteases, to form extra cellular NETS that trap and kill bacterial pathogens without the need for phagocytosis. We aim to study if pathological NETs formation could be the underlying pathology among these patients with recurrent infections and a normal screening of the immune system.
|Study Type :||Observational|
|Estimated Enrollment :||100 participants|
|Observational Model:||Case Control|
|Official Title:||The Ability of Neutrophils From Patients With Recurrent Infections to Produce Neutrophil Extracellular Traps (NET).|
|Study Start Date :||May 2010|
|Estimated Primary Completion Date :||May 2013|
|Estimated Study Completion Date :||December 2013|
- Measure NET formation in patients with recurrent infections [ Time Frame: One year ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01112592
|Contact: Ronit Gavrieli, MScemail@example.com|
|Meir Medical Center||Recruiting|
|Kfar Saba, Israel, 44281|
|Contact: Ronit Gavrieli, MSc 972-9-7472399 firstname.lastname@example.org|
|Principal Investigator: Baruch Wolach, MD|
|Sub-Investigator: Ronit Gavrieli, MSc|
|Sub-Investigator: Sivan Berger-Achituv, MD|
|Sub-Investigator: Tamar Kovalsky, Nurse|
|Principal Investigator:||Baruch Wolach, MD||Meir Medical Center|