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Phosphorous Magnetic Resonance Spectroscopy of Heart

This study is currently recruiting participants.
Verified May 2016 by Washington University School of Medicine
Sponsor:
ClinicalTrials.gov Identifier:
NCT01110395
First Posted: April 26, 2010
Last Update Posted: May 27, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Information provided by (Responsible Party):
Washington University School of Medicine
  Purpose
Heart needs constant supply of energy to continue working. Phosphorus magnetic resonance spectroscopy allows us to measure energy produced in the heart. The purpose of this study is to determine if the energy production is reduced in failing heart.

Condition
Left Ventricular Dysfunction

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: 31P Magnetic Resonance Spectroscopy of Heart

Further study details as provided by Washington University School of Medicine:

Primary Outcome Measures:
  • A MR spectroscopy technique to measure creatine kinase flux in the heart is being developed [ Time Frame: three years ]

Estimated Enrollment: 15
Study Start Date: June 2009
Estimated Study Completion Date: January 2017
Estimated Primary Completion Date: January 2017 (Final data collection date for primary outcome measure)
Groups/Cohorts
Heart Failure
Magnetic Resonance Spectroscopy

Detailed Description:
We will use non-invasive phosphorus magnetic resonance spectroscopy technique to measure creatine kinase (CK) flux in failing heart. The studies will be done on Siemens 3.0T human system. We will recruit subjects with LV dysfunction due to prior anterior wall myocardial infarction.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
The study population will be individuals with left ventricular dysfunction including men and women of all races.
Criteria

Inclusion Criteria:

  • Individuals with left ventricular dysfunction

Exclusion Criteria:

  • Age < 18, pregnant, history of excessive alcohol use, or any condition (e.g. claustrophobia, a pacemaker) that would prevent him/her from completing the magnetic resonance spectroscopy study
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01110395


Contacts
Contact: Adil Bashir, PhD 314-747-3878
Contact: Kitty Harrison, RN 314-747-0183 Harrisonk@mir.wustl.edu

Locations
United States, Missouri
Washington University in St. Louis Active, not recruiting
St. Louis, Missouri, United States, 63110
Washington University in St. Louis Recruiting
St. Louis, Missouri, United States, 63110
Contact: Adil Bashir, PhD    314-362-7403    bashira@mir.wustl.edu   
Sponsors and Collaborators
Washington University School of Medicine
Investigators
Principal Investigator: Adil Bashir, PhD Washington University School of Medicine
  More Information

Responsible Party: Washington University School of Medicine
ClinicalTrials.gov Identifier: NCT01110395     History of Changes
Other Study ID Numbers: 09-0533
First Submitted: April 22, 2010
First Posted: April 26, 2010
Last Update Posted: May 27, 2016
Last Verified: May 2016

Additional relevant MeSH terms:
Ventricular Dysfunction
Ventricular Dysfunction, Left
Heart Diseases
Cardiovascular Diseases