Positive and Expiratory Pressure and Hemorrhagic Stroke
|ClinicalTrials.gov Identifier: NCT01109355|
Recruitment Status : Completed
First Posted : April 23, 2010
Last Update Posted : April 23, 2010
|Condition or disease||Intervention/treatment|
|Stroke Hemorrhage||Other: lung mechanics ventilatory Other: Hemodynamic and intracranial pressure|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||25 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||Effect of Positive End Expiratory Pressure on Cerebral Perfusion Pressure in Adult Patients With Hemorrhagic Stroke|
|Study Start Date :||January 2008|
|Primary Completion Date :||July 2008|
|Study Completion Date :||August 2008|
Other: lung mechanics ventilatory
- Measurement of intracranial pressureThe ICP monitoring catheter was kept closed for drainage and open for monitoring, since the arrival of the surgical block, was only open for drainage if there was an increase in ICP above 20 mmHg.
- Effect of different values of PEEP on lung mechanics- Lung compliance:During the assessment protocol was changed to pressure control ventilation mode with the following values of ventilatory parameters: Pp = 30 cm H2O, inspiratory time = 1s; FiO2 = 40%, RR = 16 bpm; Sensitivity = 1 cmH2O. PEEP employed ranged from 0 to 14 cmH2O.
- Effect of different PEEP levels on aspects hemodynamicAt each value of PEEP the patient was ventilated for a period of five minutes to carry out monitoring of heart rate and cerebral perfusion pressure(CPP).
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01109355
|Recife, Pernambuco, Brazil|
|Study Chair:||Roberto Campelo||Universidade Federal de Pernambuco|