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Evaluation of Phenotypic and Genetic Properties in Male Subjects Affected By Hypohidrotic Ectodermal Dysplasia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01108770
Recruitment Status : Completed
First Posted : April 22, 2010
Last Update Posted : August 21, 2012
Information provided by (Responsible Party):
Edimer Pharmaceuticals

Brief Summary:
To characterize skin properties in male subjects with HED

Condition or disease
Ectodermal Dysplasia

Detailed Description:

This study is designed to obtain information from male subjects with HED and unaffected male control subjects. The study will consist of the standardized collection of data from HED medical history questionnaires and non-invasive tests. A subset of subjects will undergo genetic testing. All data will be collected from families attending the 2010 NFED Family Conference, July 22-24, 2010, in Colorado Springs, CO.

Since HED is a rare disease, it is difficult to obtain reliable data on a sufficient number of subjects in any one region. The NFED Family Conference is a location where families affected with HED come together, and therefore, presents an ideal location to obtain data needed to design future studies. As the procedures are non-invasive and are designed to take a relatively short period of time, subjects can participate in this study while attending the NFED Family Conference.

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Study Type : Observational
Actual Enrollment : 62 participants
Official Title: Evaluation of Phenotypic and Genetic Properties in Male Subjects With Hypohidrotic Ectodermal Dysplasia and Their Family Members
Study Start Date : July 2010
Actual Primary Completion Date : July 2010
Actual Study Completion Date : October 2010

HED affected males
Unaffected male controls

Primary Outcome Measures :
  1. Characterization of skin properties in HED affected male subjects compared with healthy controls [ Time Frame: Two assessments conducted once during study day. ]
    The primary objective of this descriptive study is to use skin assessment techniques to characterize skin properties in male subjects affected by HED compared with healthy controls including determination of the number of sweat glands and the rate of sweating.

Secondary Outcome Measures :
  1. Collecting demographic information and clinical status in male subjects affected by HED using a medical questionnaire. [ Time Frame: Collected once during study day. ]
  2. Testing for the presence of ectodysplasin A (EDA) gene mutations in a subset of subjects enrolled in this study. [ Time Frame: Collected once during study day. ]

Biospecimen Retention:   Samples With DNA
Blood samples

Information from the National Library of Medicine

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Ages Eligible for Study:   1 Year and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Male subjects with HED or unaffected controls

Inclusion Criteria:

  1. Registered and attending the 2010 NFED Family Conference;
  2. One year of age or greater;
  3. Conform to one of the following requirements for providing informed consent:

    • if more than 18 years of age, subjects must provide signed informed consent;
    • if less than 18 years of age and it is determined that the subject is capable of providing assent, both the assent of the subject and consent of the parent(s) or guardian of that subject must be granted. Under this condition, both parents of the subject should give their permission, unless 1 parent is deceased, unknown, incompetent, or not available;
    • if the subject is incapable of providing assent, the consent of the parent(s) or guardian of the subject must be granted. Under this condition, both parents should give their consent, unless 1 parent is deceased, unknown, incompetent, or not available.
  4. Subjects must meet one of the following criteria:

    • Male subjects of original gender with the clinical characteristics of HED, including at least a history of decreased sweating and either abnormal teeth (fewer permanent teeth, teeth are smaller than average and often have conical crowns), and/or sparseness of scalp and body hair;
    • Healthy male controls, i.e. either unaffected male family members or unaffected male volunteers.

Exclusion Criteria:

  1. Known hypersensitivity to pilocarpine or pilocarpine-like muscarinic agonists.
  2. Presence of pacemakers.
  3. Subjects who are not able or are not willing to comply with the procedures of this protocol.
  4. Subjects with any major medical problem that will prevent them from participating in this study.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01108770

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United States, Colorado
Cheyenne Mountain Resort
Colorado Springs, Colorado, United States, 80906
Sponsors and Collaborators
Edimer Pharmaceuticals
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Principal Investigator: Dorothy K Grange, MD Washington University School of Medicine
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Responsible Party: Edimer Pharmaceuticals Identifier: NCT01108770    
Other Study ID Numbers: ECP-001
First Posted: April 22, 2010    Key Record Dates
Last Update Posted: August 21, 2012
Last Verified: August 2012
Keywords provided by Edimer Pharmaceuticals:
Hypohidrotic Ectodermal Dysplasia
Additional relevant MeSH terms:
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Ectodermal Dysplasia
Ectodermal Dysplasia 1, Anhidrotic
Pathologic Processes
Abnormalities, Multiple
Congenital Abnormalities
Skin Abnormalities
Skin Diseases, Genetic
Genetic Diseases, Inborn
Skin Diseases
Genetic Diseases, X-Linked