Integrated Whole-Genome Analysis of Hematologic Disorders
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We will use new technologies to look at the DNA, RNA, proteins, and metabolites in the disease-containing blood, bone marrow, or tissue and normal cells from the skin. Our goal is to analyze all of the genes in the diseased and normal skin sample. By comparing the results of the diseased sample and normal skin cells and the results of the two types of genetic information (DNA and RNA), we should be able to identify genetic changes that are important for the initiation, progression, or treatment response of that particular disorder.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
participants with hematologic disorders
18 years of age or older
Patient meets the clinical and/or pathologic criteria for the hematologic disorder being examined.
Patient is willing to provide a skin biopsy and five 10 mL tubes of peripheral blood.
Less than 18 years of age
Patient is not willing to provide a skin biopsy and five 10 mL tubes of peripheral blood.