Regional Lung Opening and Closing Pressures in Patients With Acute Lung Injury
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|ClinicalTrials.gov Identifier: NCT01107847|
Recruitment Status : Unknown
Verified March 2010 by University of Schleswig-Holstein.
Recruitment status was: Recruiting
First Posted : April 21, 2010
Last Update Posted : April 21, 2010
|Condition or disease||Intervention/treatment||Phase|
|Acute Lung Injury||Procedure: low flow pressure volume manoeuvre||Not Applicable|
During artificial ventilation the cyclic opening and closing of alveoli during artificial ventilation results in patients with acute lung injury (ALI) in a higher mortality. A positive endexpiratory pressure (PEEP) is applied with the intention to avoid these cyclic opening and closing of alveoli. The distribution of ventilation in patients with ALI is extremely inhomogeneous, consequently there are different regional opening pressures needed to open up the alveoli and avoid closing. Finding the best level of PEEP in patients with injured lungs to avoid atelectasis and alveolar strain induced by inadequately high or low PEEP levels is a challenge.
The purpose of this study is to develop a protocol for measuring regional opening and closing pressures using the method of electrical impedance tomography in lung healthy and ALI patients. A ventilator setting guided by regional opening and closing pressures might help reducing the impairment of the lung by artificial ventilation.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||25 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Measurement of Regional Lung Opening and Closing Pressures in Patients With Acute Lung Injury Using Electrical Impedance Tomography|
- Procedure: low flow pressure volume manoeuvre
In all patients a standard low flow pressure volume manoeuvre is applied by a respirator with a constant gas flow of 4 l/min starting at a zero end-expiratory pressure up to a tidal volume of 2 l or until a maximum airway pressure of 35 cm H2O was reached.
- Measurement of regional lung opening pressures [ Time Frame: one year ]For the measurement of regional opening pressures in lung healthy and acute lung injury an inspiratory low flow manoeuvre with synchronous measurement of regional ventilation and airway pressure is performed. The regional opening pressures are defined as the airway pressure to the point were the regional lung areas open up.
- Measurement of regional closing pressures [ Time Frame: one year ]For the measurement of regional closing pressures in lung healthy and acute lung injury an expiratory low flow manoeuvre with synchronous measurement of regional ventilation and airway pressure is performed. The regional closing pressures are defined as the airway pressure to the point were the regional lung areas start closing.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01107847
|Contact: Sven Pulletz, M.D.||+49 431 597 firstname.lastname@example.org|
|Department of Anesthesiology and Intensive Care Medicine, University Medical Center of Schleswig-Holstein, Campus Kiel||Recruiting|
|Kiel, Germany, 24105|
|Contact: Sven Pulletz, M.D. + 49 431 597 2991 email@example.com|
|Contact: Inéz Frerichs, M.D. + 49 431 597 2991 firstname.lastname@example.org|
|Sub-Investigator: Sven Pulletz, M.D.|
|Sub-Investigator: Matthias Kott, M.D.|
|Sub-Investigator: Gunnar Elke, M.D.|
|Sub-Investigator: Dirk Schaedler, M.D.|
|Sub-Investigator: Guenther Zick, M.D.|
|Sub-Investigator: Barbara Gawelczyk, M.D.|
|Principal Investigator: Norbert Weiler, M.D.|
|Study Chair:||Jens Scholz, M.D.||University Medical Center of Schleswig-Holstein, Campus Kiel, Department of Anesthesiology and Intensive Care Medicine|