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Vasopressin Deficiency in Hemorrhagic Shock

This study has been completed.
Information provided by (Responsible Party):
The University of Texas Health Science Center at San Antonio Identifier:
First received: April 19, 2010
Last updated: March 7, 2012
Last verified: March 2012
In this study we hope to delineate the typical vasoactive mediator response of trauma patients to shock. We plan to assess serum levels of vasopressin and also catecholamines, angiotensin, and cortisol during resuscitation of trauma patients to delineate high risk populations for vasopressin deficiency.

Condition Intervention
Body Response to Trauma
Other: Phlebotomy

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Vasopressin Deficiency in Hemorrhagic Shock

Resource links provided by NLM:

Further study details as provided by The University of Texas Health Science Center at San Antonio:

Enrollment: 81
Study Start Date: February 2010
Study Completion Date: April 2011
Groups/Cohorts Assigned Interventions
trauma patient
SBP less than 90mmHg
Other: Phlebotomy
Blood draws (total 48 cc blood)

Detailed Description:
This is a prospective observational study. The only research-driven procedure will be the removal of blood samples at designated time points(total blood removed 48 cc per patient). Hemodynamic, fluid infusion and agitation/pain data (RAMSEY Score) will prospectively be collected for research purposes. We will collect data from a convenience sample of patients (when research staff is available) over a one year period.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
observational study - trauma patients admitted to University Hospital

Inclusion Criteria:

  • Patient is a male or female patient presumed to be at least 18 years of age;
  • Patient has a reported or actual systolic blood pressure < 90 mmHg within 1 hour of arrival to the Emergency Room;
  • Patient has clinical evidence of acute traumatic injury;

Exclusion Criteria:

  • Patient is asystolic or requires CPR prior to arrival;
  • Patient was transferred from an outside facility
  • Patient known to be pregnant
  • Patient known to be prisoner
  Contacts and Locations
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Please refer to this study by its identifier: NCT01107314

United States, Texas
San Antonio, Texas, United States, 78229-3900
Sponsors and Collaborators
The University of Texas Health Science Center at San Antonio
Principal Investigator: Stephen M Cohn, MD The University of Texas Health Science Center at San Antonio
  More Information

Responsible Party: The University of Texas Health Science Center at San Antonio Identifier: NCT01107314     History of Changes
Other Study ID Numbers: 2009-0528-H
A-13969.2 ( Other Grant/Funding Number: DoD )
Study First Received: April 19, 2010
Last Updated: March 7, 2012

Additional relevant MeSH terms:
Shock, Hemorrhagic
Diabetes Insipidus, Neurogenic
Pathologic Processes
Diabetes Insipidus
Kidney Diseases
Urologic Diseases
Pituitary Diseases
Endocrine System Diseases
Arginine Vasopressin
Vasoconstrictor Agents
Antidiuretic Agents
Natriuretic Agents
Physiological Effects of Drugs processed this record on May 22, 2017