Avian Influenza Studies In Lebanon
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|ClinicalTrials.gov Identifier: NCT01107262|
Recruitment Status : Completed
First Posted : April 20, 2010
Last Update Posted : October 27, 2011
The highly pathogenic avian influenza (HPAI) H5N1 virus arrived in the Middle East in 2005 and has since established itself in local domestic birds and is now considered endemic in several Middle Eastern countries.Few studies indicate the presence of low pathogenicity avian influenza (LPAI) viruses of the H9 type among Lebanese poultry and wild birds. These studies also provide some evidence suggesting that humans exposed to these sick birds are showing elevated antibody titers against these LPAI H9 viruses.
This study will focus on the following objectives:
- To determine the seroprevalence of AI in poultry-exposed and non-exposed human populations.
- To identify risk factors associated with AI infections in occupationally-exposed poultry workers.
- To conduct nation-wide cross-sectional surveillance for AI viruses among domestic birds in low biosecurity farms and backyard flocks.
|Condition or disease|
|Avian Influenza Virus Diseases|
This study will examine the sera of 200 poultry-exposed adults and 50 adult controls and administer questionnaires to identify risk factors for AI infections in human beings.Study volunteers will be interviewed regarding their exposures, medical history, and behaviors using a close-ended questionnaire specifically tailored for this study. A blood sample will be collected from every participant to verify presence of antibodies against the viruses under study. All study materials are in English and Arabic. Along side the human aspect of the study, specimens will be collected from the birds that the individual handles.
This study hypothesizes that they will find evidence of previous infection with these viruses among poultry workers. Furthermore, the study team will collect animal specimens from the farms of the study volunteers and determine the types of Avian Influenza viruses that they harbour.
|Study Type :||Observational|
|Actual Enrollment :||250 participants|
|Observational Model:||Case Control|
|Official Title:||Avian Influenza Studies In Lebanon|
|Study Start Date :||July 2009|
|Actual Primary Completion Date :||December 2010|
|Actual Study Completion Date :||December 2010|
Poultry exposed adults
This seroepidemiological study proposes to compare adults with occupational exposure to poultry with non-poultry exposed adult controls for evidence of previous infections with AI viruses.In this study, any person with occupational exposure to poultry i.e. works in poultry production facility or raises a smaller number of poultry on his/her farm will be considered exposed. The questionnaire used in this study will capture poultry exposure data through a group of variables assessing type of occupational setting, length of time of exposure, flock size, type of work performed, and personal protective equipment (PPE) used.
Poultry Non-exposed Adult Controls
Controls, adults who were never exposed to poultry, will be enrolled from urban areas such as the capital Beirut. Controls will be invited to volunteer by word of mouth at public/community sites.
- The seroprevalence of Avian Influenza in poultry-exposed and non-exposed human populations. [ Time Frame: 1 year ]
- Risk factors associated with AI infections in occupationally-exposed poultry workers. [ Time Frame: 1 year ]
- Nation-wide cross-sectional surveillance for AI viruses among domestic birds in low biosecurity farms and backyard flocks. [ Time Frame: 1 year ]
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01107262
|United States, Tennessee|
|St. Jude Children's Research Hospital|
|Memphis, Tennessee, United States, 38105|
|American University of Beirut|
|Beirut, Lebanon, 1107-2020|
|Principal Investigator:||Mohammad Ghazi Kayali, Ph.D, MPH||St. Jude Children's Research Hospital|