Associations Between Diabetes, Arterial Stiffness and Fibulin-1 in Patients Undergoing Heart- and Vascular Surgery?
|ClinicalTrials.gov Identifier: NCT01106573|
Recruitment Status : Unknown
Verified April 2010 by Odense University Hospital.
Recruitment status was: Not yet recruiting
First Posted : April 20, 2010
Last Update Posted : April 20, 2010
Diabetes Mellitus (DM) is frequently appearing in patients with cardiovascular disease and these patients, as a consequence herby, has a lesser prognosis. DM is often related to increased arterial stiffness and hypertension. The investigators thesis is that DM and pre-diabetes is prevalent in patients undergoing cardiovascular surgery and to some extend is under-diagnosed. At the same time the investigators imagine that DM is closely related to the degree of arterial stiffness, and that these parameters are closely related to a new biochemical marker, fibulin-1.
The investigators aim to describe the prevalence of type 2 DM and dysmetabolism in patients admitted to the hospital to undergo cardiovascular surgery and besides that to investigate if there is a connection between the degree of the dysmetabolism and arterial disease, by studying arterial stiffness and by measuring a new biochemical marker, fibulin-1, which the investigators newly have identified. The results of this project will give us a measure for the quantity of unknown DM in patients undergoing cardiovascular surgery and furthermore tell us more in terms of the connections between a newly identified plasma arterial marker, arterial stiffness and diabetes.
|Condition or disease|
|Coronary Artery Disease Arteriosclerosis Carotid Stenosis Thrombosis Aortic Aneurysm, Abdominal|
|Study Type :||Observational|
|Estimated Enrollment :||1400 participants|
|Official Title:||Is There an Association Between the Presence of Diabetes, the Degree of Arterial Stiffness and a New Plasma Marker for Vascular Elasticity, Fibulin-1 in Patients Undergoing Heart- and Vascular Surgery?|
|Study Start Date :||June 2010|
|Estimated Primary Completion Date :||May 2013|
|Estimated Study Completion Date :||May 2013|
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01106573
|Contact: Maria Lyck Hansen, Ph.d firstname.lastname@example.org|
|Contact: Lars Melholt Rasmussen, Professor, MD||0045-6541 email@example.com|
|Department of Biochemnistry and Farmacology, Odense University Hospital||Not yet recruiting|
|Odense, Denmark, 5000|
|Principal Investigator: Maria Lyck Hansen, Ph.d student|
|Study Chair:||Lars Melholt Rasmussen, Professor, MD||Department of Biochemnistry and Farmacology, Odense University Hospital|