Genetics of Motor Learning
- New studies in human genetics have revealed information about genetic connections to memory and motor behavior. Researchers are interested in investigating the role of genetics in motor learning, in conjunction with related studies taking place in the Human Motor Control Section of the National Institute of Neurological Diseases and Stroke (NINDS). Participants in motor learning studies conducted at NINDS will be asked to provide blood samples for further evaluation.
- To create a repository of blood samples from patients and healthy subjects who are participating in NINDS motor learning studies.
- Individuals between 18 and 100 years of age who are or will be participating in motor learning research studies at the National Institutes of Health.
- Blood draws for genetic testing will usually be done on the same day as the motor learning study. Participants will provide one blood sample for research.
- No treatment will be provided under this study.
|Parkinson s Disease Dystonic Disorders Focal Dystonia Movement Disorders|
|Study Design:||Time Perspective: Prospective|
|Official Title:||Genetics of Motor Learning|
- Genetic polymorphism frequency (e.g. BNDF Va166Met) compared to measures of motor learning (e.g. reaction time or fMRI BOLD signal change)
|Study Start Date:||April 14, 2010|
|Estimated Study Completion Date:||December 21, 2015|
The objective of this study is to create a bio-repository of blood samples from patients and healthy subjects who are participating in NINDS motor learning studies. Blood will be analyzed for BDNF and samples stored for future genetic studies. . A variety of genes that may affect motor learning are being increasingly identified, and variations among these genes, referred to as polymorphisms, may help explain individual differences.
STUDY POPULATION: <TAB>
We will enroll up to five hundred healthy volunteers and five hundred volunteers with movement difficulties who are between the ages of 18 and 100 and who are already participating, or will be participating, in other protocols dealing with motor learning research studies at the National Institutes of Health (NIH).
This is an observational and repository protocol that involves a single blood sample for genetic analysis. This will allow the genetic characterization of subjects participating in motor learning protocols to be analyzed and tested for the role of genetics in motor learning results.
We will compare genetic variations with the different behavioral, electrophysiologic, imaging, or other outcomes acquired in the associated motor learning studies. Thus, we will determine whether specific polymorphisms are associated with different measures of motor learning.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01105845
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike|
|Bethesda, Maryland, United States, 20892|
|Principal Investigator:||Mark Hallett, M.D.||National Institute of Neurological Disorders and Stroke (NINDS)|