Optimal Flow Rate During Cardiopulmonary Bypass
|ClinicalTrials.gov Identifier: NCT01105078|
Recruitment Status : Unknown
Verified August 2014 by Arndt-H. Kiessling, Johann Wolfgang Goethe University Hospital.
Recruitment status was: Recruiting
First Posted : April 16, 2010
Last Update Posted : August 6, 2014
Regardless of the development of cardiac surgery techniques and technologies, the question of an optimal extracorporeal circulation is still unanswered. There are globally accepted standards of perfusion, however, keep many of these procedures was not evidence-based review.
Generally accepted are flow rates during cardiopulmonary bypasses of 2.5 L/min/m2. This target was derived from the physiological conditions, but they are not the result of an adapted adjustment to the fundamentally non-physiological processes during extracorporeal circulation. Among other things, an increased metabolic demand during re-perfusion is not taken into account.
An increasing and optimizing of the standard flow rate of 0.5 L/min/m2 should be the aim of this investigation. Under optimal perfusion, the investigators are maintaining the microcirculation and organ protection in receipt of endothelial function and oxygen transport.
|Condition or disease||Intervention/treatment||Phase|
|Tissue Perfusion||Procedure: Flow rate||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||60 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Optimal Flow Rate During Cardiopulmonary Bypass|
|Study Start Date :||May 2010|
|Estimated Primary Completion Date :||December 2015|
Comparison between a flow rate of 2.5/l/min/m2 versus 3.0/l/min/m2
Procedure: Flow rate
Different flow rate during cardiopulmonary bypass
- Microcirulation [ Time Frame: intraooperative ]measurement with O2C
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01105078
|Contact: Arndt H Kiessling, MD||+49696301 ext email@example.com|
|Johann Wolfgang Goethe University Hospital||Recruiting|
|Frankfurt am Main, Germany, 60590|
|Contact: Arndt H Kiessling, MD +49696301 ext 6705 firstname.lastname@example.org|
|Principal Investigator: Andreas Zierer, MD|
|Sub-Investigator: Arndt H Kiessling, MD|
|Sub-Investigator: Eduard Manherz|