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Postoperative Cognitive Dysfunction After Total Knee or Hip Replacement Surgery in Fast-track Set-up

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ClinicalTrials.gov Identifier: NCT01103752
Recruitment Status : Completed
First Posted : April 15, 2010
Last Update Posted : December 14, 2011
Sponsor:
Collaborator:
Lundbeck Foundation
Information provided by (Responsible Party):
Lene Krenk, Rigshospitalet, Denmark

Brief Summary:
The aim of this study is to quantify the incidence of postoperative cognitive dysfunction in the elderly patient (>60y) after total hip or knee replacement surgery. The hypothesis is that the fast-track methodology with a mean hospital stay less than 3 days will help to minimize this reduction in memory and concentration.

Condition or disease Intervention/treatment
Postoperative Cognitive Dysfunction Other: no intervention, descriptive study

Study Type : Observational
Actual Enrollment : 225 participants
Time Perspective: Prospective
Official Title: Postoperative Cognitive Dysfunction After Total Knee or Hip Replacement Surgery in Fast-track Set-up
Study Start Date : October 2009
Primary Completion Date : September 2011
Study Completion Date : December 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Hip Replacement
U.S. FDA Resources

Group/Cohort Intervention/treatment
Surgery
This group (n=220) consist of patients undergoing hip or knee replacement in a fast-track setup and they are tested 3 times for postoperative cognitive dysfunction.
Other: no intervention, descriptive study
no intervention, descriptive study




Information from the National Library of Medicine

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Ages Eligible for Study:   60 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
patients undergoing fast-track knee or hip replacement surgery at one of the hospitals participating (Hidovre, Holstebro, Hørsholm, Århus)
Criteria

Inclusion Criteria:

  • 60 years of age or above
  • ASA classification 1-4
  • undergoing fast-track hip or knee replacement

Exclusion Criteria:

  • anaesthesia within the past 90 days
  • daily consumption of sleep or anxiety medication
  • more than 35 units of alcohol per week
  • lack of proper verbal and reading skills, Danish
  • Serious hearing or visual impairment
  • Mini mental status evaluation (MMSE) < 24
  • Parkinsons Disease or other neurological disease causing functional impairment

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01103752


Locations
Denmark
The Lundbeck Centre for fast-track hip/knee surgery
Copenhagen, Denmark
Sponsors and Collaborators
Lene Krenk
Lundbeck Foundation
Investigators
Principal Investigator: Lene Krenk, Doctor Rigshospitalet, Denmark

Responsible Party: Lene Krenk, MD, Rigshospitalet, Denmark
ClinicalTrials.gov Identifier: NCT01103752     History of Changes
Other Study ID Numbers: H-3-2009-096
First Posted: April 15, 2010    Key Record Dates
Last Update Posted: December 14, 2011
Last Verified: December 2011

Additional relevant MeSH terms:
Cognitive Dysfunction
Cognition Disorders
Neurocognitive Disorders
Mental Disorders