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Prophylactic Selective Lateral Neck Dissection in Patients With Papillary Thyroid Carcinoma

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ClinicalTrials.gov Identifier: NCT01103557
Recruitment Status : Completed
First Posted : April 14, 2010
Last Update Posted : April 14, 2010
Sponsor:
Information provided by:
Pusan National University Hospital

Brief Summary:
The purpose of this study is to prospectively analyze the incidence of occult lateral neck metastasis (LNM) and to elucidate the factors that predict LNM in papillary thyroid carcinoma (PTC) with central neck metastasis (CNM) by performing prophylactic selective lateral neck dissection (SND).

Condition or disease Intervention/treatment
Thyroid Neoplasm Lymphatic Metastasis Procedure: prophylactic selective lateral neck dissection

Detailed Description:
The lymphatic drainage pattern of the thyroid is uniform and consistent, and therefore, metastatic patterns are relatively predictable. Initial nodal metastasis in PTC usually occurs in the paratracheal and pretracheal nodes in level VI of the central compartment of the ipsilateral neck and spreads to the lateral cervical lymph nodes. Macroscopic skip metastases to the lateral compartment of the neck in the absence of central disease are uncommon.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 62 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: The Effectiveness of Prophylactic Selective Lateral Neck Dissection in Papillary Thyroid Carcinoma Patients With Central Neck Metastasis

Resource links provided by the National Library of Medicine

Drug Information available for: Thyroid
U.S. FDA Resources


Intervention Details:
    Procedure: prophylactic selective lateral neck dissection
    Level II, III, IV lymph node dissection



Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 76 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Papillary thyroid carcinoma with central neck metastasis
  • No evidence of lateral neck metastasis as determined by high-resolution neck ultrasonography and computed tomography

Exclusion Criteria:

  • History of previous thyroid operation
  • Isthmic thyroid lesion

Responsible Party: Yun-Sung Lim, Pusan National University Hospital
ClinicalTrials.gov Identifier: NCT01103557     History of Changes
Other Study ID Numbers: PTC_CND_LND
First Posted: April 14, 2010    Key Record Dates
Last Update Posted: April 14, 2010
Last Verified: January 2010

Keywords provided by Pusan National University Hospital:
Papillary thyroid carcinoma with neck metastasis
neck dissection

Additional relevant MeSH terms:
Carcinoma
Neoplasm Metastasis
Thyroid Diseases
Thyroid Neoplasms
Lymphatic Metastasis
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
Neoplastic Processes
Pathologic Processes
Endocrine System Diseases
Endocrine Gland Neoplasms
Neoplasms by Site
Head and Neck Neoplasms