Cross-Education Of Contralateral Antagonists
Previous studies well documented the impact of unilateral training of limb muscle on the untrained contralateral homologous muscle. The aim of this study is to evaluate whether the electrical muscle stimulation on the dominant wrist flexors for 6 weeks cause an increase in the muscle strength of the contralateral wrist extensors in healthy adult men.
Ethical approval was obtained from Institutional Review Board. All participants were volunteers and provided written informed consent. Among young adult males working in our hospital, 30 subjects who voluntarily accepted to participate in this study were assessed for eligibility. Twenty three young-adult healthy males were included in this double-blind prospective study. These volunteers were randomized into two groups. In Electrical Muscle Stimulation (EMS) group, electrical muscle stimulation of the right wrist flexor muscles was applied; in Controls, transcutaneous electrical nerve stimulation was applied. Electrodes were placed over the flexor aspect of the right forearm in both groups. Electrical stimulation was applied for thirty sessions (one session a day, five days a week for six weeks) in both groups by the same researcher. Compex2 (Medicompex SA, Switzerland) was used for electrical stimulation. Isokinetic torque was measured in the right and left wrist flexors and extensors before and after trial. Isokinetic torque was measured in the right (trained) and left (untrained) forearm with the Cybex (Humac 2004/Norm) extremity-testing system.
|Muscle Strength Quantitative Trait Locus 1||Procedure: Experimental group Procedure: Control group|
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Outcomes Assessor)
Primary Purpose: Basic Science
|Official Title:||Cross-Education Of Muscular Strength: Is Cross-Training Effects Confined To Untrained Contralateral Homologous Muscle|
- Changes in Muscle Strength in the Contralateral Untrained Wrist Muscles [ Time Frame: 6 weeks (The change calculated as 6 months minus baseline) ]Isokinetic torque was measured in the contralateral untrained wrist muscles with the Cybex (Humac 2004/Norm) extremity-testing system before and after experiment.
|Study Start Date:||January 2008|
|Study Completion Date:||June 2009|
|Primary Completion Date:||April 2009 (Final data collection date for primary outcome measure)|
Experimental: Electrical Muscle Stimulation
Electrical muscle stimulation of the right wrist flexor muscles was applied
Procedure: Experimental group
Electrical muscle stimulation (EMS) of the right wrist flexor muscles was applied. EMS was applied for 20 minutes. Maximum current intensity tolerated was used so as to stimulate the highest possible number of motor unit. The stimulation intensity increased every five minutes during a session. Electrical stimulation was applied for thirty sessions (one session a day, five days a week for six weeks.)
Other Name: Electrical Muscle Stimulation
Sham Comparator: Control
Transcutaneous electrical nerve stimulation was applied
Procedure: Control group
Conventional mode of transcutaneous electrical nerve stimulation (TENS) was applied for the control subjects. TENS was applied for 20 minutes. The stimulus intensity was adjusted as the lowest current at which the subject felt only a slight tickling of the impulses. A visible, and palpable muscle contraction was not provided during TENS stimulation. The stimulus intensity was not changed during the first session. Subsequently, TENS was applied at same intensity in all sessions. TENS was applied for thirty sessions (one session a day, five days a week for six weeks).
Other Name: Transcutaneous electrical muscle stimulation
It has been reported that strength training of unilateral limb causes an increase in voluntary strength not only in the trained limb, but also in the contralateral untrained limb. This phenomenon is known as "cross-education, cross-training or contralateral strength training effect" . Cross-education of muscle strength can occur in both upper and lower limb muscles.It is not gender and age specific and can occur with training accomplished by voluntary effort, electrical stimulation of muscles or mental practice of unilateral contractions. Electrostimulation is one of the most efficient methods to induce cross-education.
Although it is clear that unilateral training has a contralateral effect, the mechanisms behind this effect remain unclear. Because of the specific nature of cross education, modification in neural function is the more likely mechanism underlying this effect. The potential neural mechanisms can be broadly categorized as either ''central" or ''peripheral (spinal)" adaptations. Central neural mechanisms involved in the excitation of the relevant part of the cortex during voluntary contraction of the trained limb are thought to produce contralateral facilitation. The cross-extension reflex is the primary spinal neural mechanism for cross-education.
In the studies performed up today, the contralateral effects of unilateral training were evaluated in the contralateral homologous muscles. However it's not reported whether a change in the muscle strength have been observed in the antagonists of the contralateral homologous muscles. In a study, after one session of unilateral surface electrical stimulation of the rectus femoris, an increase in the isometric force and EMG activity of the contralateral rectus femoris, but a decrease in the EMG activity of the contralateral biceps femoris was reported in adult men. It's proposed that, the EMG activity decrease in the biceps femoris may be explained by cross-extension reflex. The effect of long-time exercise or electrical muscle stimulation on the antagonists of the contralateral homologous muscles is not clear.
The aim of this study is to evaluate whether the electrical muscle stimulation on the dominant wrist flexors for 6 weeks cause an increase in the muscle strength of the contralateral wrist extensors in healthy adult men.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01103232
|Study Chair:||ILHAN KARACAN, MD||Vakif Gureba Training & Research Hospital|