Effect of Food Form on Satiety and Gastric Emptying
Our objective is to determine whether food form (liquid vs. solid) alters gastric emptying, satiety, and food intake, when all macronutrients and fiber are controlled. The study population will include 10 healthy women, who have a normal body mass index. We have chosen to evaluate only women because this is a small pilot study and one of our endpoints is gastric emptying. Gastric emptying is known to differ between men and women. Gastric emptying will be evaluated using the Smartpill technology, satiety will be evaluated using computerized visual analog scales/questions, and food intake will be measured by providing subjects with an ad libitum/buffet-style lunch.
Our hypothesis is that our subjects will be less hungry after they eat a solid breakfast compared to a liquid breakfast. We also hypothesize that our subjects will have a slower gastric emptying time after they eat the solid meal. Lastly, we think subjects will want to eat less food at lunch time if they have eaten a solid meal compared to a liquid meal for breakfast.
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Beverages and Obesity: Effect of Food Form on Satiety and Hunger|
- Determine whether food form (liquid vs. solid) alters gastric emptying time when all macronutrients and fiber are controlled. [ Time Frame: May 2010 to December 2010 ] [ Designated as safety issue: No ]Subjects will consume both liquid and solid meals and we will evaluate and compare gastric emptying time after each of them.
- Determine whether food form (liquid vs. solid) alters satiety and food intake when all macronutrients and fiber are controlled. [ Time Frame: May 2010 to December 2010 ] [ Designated as safety issue: No ]Subjects will consume both liquid and solid meals and we will evaluate and compare appetite and food intake after each of them.
|Study Start Date:||May 2010|
|Study Completion Date:||September 2010|
|Primary Completion Date:||September 2010 (Final data collection date for primary outcome measure)|
Other: Liquid Breakfast
The liquid breakfast meal will contain 370 calories and will consist of fruit juices and skim milk
Other: Solid Breakfast Meal
The solid breakfast will contain 370 calories and will consist of oatmeal, golden delicious apples, blueberries, skim milk, and brown sugar.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01102907
|United States, Minnesota|
|University of Minnesota|
|St. Paul, Minnesota, United States, 55108|
|Principal Investigator:||Holly J Willis, PhD||University of Minnesota - Clinical and Translational Science Institute|