Endomicroscopy and Crohn´s Disease
The main objective of this study is to determine endomicroscopic features of Crohn´s disease.
Crohn´s disease is an inflammatory disease of the intestines that may affect any part of the gastrointestinal tract from anus to mouth, causing a wide variety of symptoms. Diagnosis is based on several histologic features including transmural pattern of inflammation, crypt abscesses and granulomas. Confocal laser endomicroscopy (CLE) is rapidly emerging as a valuable tool for gastrointestinal endoscopic imaging, enabling the endoscopist to obtain an "optical biopsy" of the gastrointestinal mucosa during the endoscopic procedure.
In patients with Crohn´s disease.
|Study Design:||Time Perspective: Prospective|
|Official Title:||Confocal Laser Endomicroscopy in Patients With Crohn´s Disease|
- To determine endomicroscopic features of Crohn´s disease. [ Time Frame: October 2009 until May 2010 ] [ Designated as safety issue: Yes ]
- Comparison of CLE findings with conventional histology. [ Time Frame: October 2009 until May 2010 ] [ Designated as safety issue: Yes ]
|Study Start Date:||October 2009|
|Study Completion Date:||August 2011|
|Primary Completion Date:||August 2011 (Final data collection date for primary outcome measure)|
Patients underwent colonoscopy for the evaluation of Crohn´s disease. During the endoscopic procedure CLE will be performed.
The patient underwent colonoscopy. During the procedure the patient will receive intravenous fluorescein or topical mucosal staining with acriflavin or cresyl violet, followed by in-vivo CLE of the tissue. Confocal images are digitally saved and analyzed afterwards.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01102855
|Department of Medicine I, University of Erlangen-Nuremberg|
|Erlangen, Germany, 91054|
|Study Director:||Markus F. Neurath||University of Erlangen-Nürnberg|