Vitamin D Insufficiency and Deficiency in Chronic Kidney Disease (CKD) Patients in Singapore
This study has been completed.
First Posted: April 13, 2010
Last Update Posted: November 7, 2014
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National Kidney Foundation, Singapore
Information provided by:
National University, Singapore
Vitamin D insufficiency and deficiency is common in chronic kidney disease (CKD) patients and is associated with elevated parathyroid hormone (PTH) concentration and mineral and bone disorder (MBD). There is also increasing evidence to show that these abnormalities increase cardiovascular morbidity and mortality in CKD patients. There is a need for early identification of vitamin D insufficiency/deficiency in CKD patients to prevent its long-term complications. However, the vitamin D status of CKD patients in Singapore has not been well described. The purpose of this study is to assess the vitamin D status of predialysis CKD patients in a tertiary academic teaching hospital in Singapore, and its association with parameters for MBD. Predialysis patients from the outpatient renal clinic at the National University Hospital (NUH) will be recruited into this study. Blood samples from the patients will be collected after an overnight fast to determine their serum 25(OH)D, creatinine, phosphorus, calcium, albumin and i-PTH concentrations. These parameters will be compared among patients in various stages of CKD.
Stage 2-5 Chronic Kidney Disease
||Time Perspective: Cross-Sectional
||Prevalence of Vitamin D Insufficiency and Deficiency in Chronic Kidney Disease Patients in Singapore
Primary Outcome Measures:
| Study Start Date:
| Study Completion Date:
| Primary Completion Date:
||July 2014 (Final data collection date for primary outcome measure)
Chronic kidney disease
All patients with stage 2-5 (pre-dialysis) chronic kidney disease
One-time blood draw (10 ml)