Satiety Response of Short Chain Fructooligosaccharide
Populations that report high fiber consumption demonstrate lower rates of obesity. Enhanced satiety may play a key role in this relationship. The colonic fermentation of fibers is theorized to influence satiety and food intake. Short chain fructooligosaccharide (scFOS) are rapidly fermentable fibers that can easily be added to foods to impact these parameters.
The objective of this study was to evaluate the satiety response of scFOS and its ability to decrease food intake.
|Healthy||Dietary Supplement: Short chain fructo-oligosaccharide (scFOS) 5 g Other: Placebo Dietary Supplement: Short chain fructooligosaccharide (scFOS) 8 g||Early Phase 1|
|Study Design:||Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Participant, Investigator)
Primary Purpose: Prevention
|Official Title:||Satiety Response of Short Chain Fructooligosaccharide|
- Satiety response using visual analogue scales [ Time Frame: 0, 15, 30, 45, 60, 90, 120, 180, 240 minutes postprandially ]Satiety response was measured using subjective perceptions of hunger, fullness, satisfaction, and prospective food intake evaluated by previously validated visual analogue scales (VAS).
- Ad libitum food intake [ Time Frame: 240 minutes postprandially and over 24 hours ]
- Breath hydrogen response [ Time Frame: 0, 240 minutes ]
- Gastrointestinal tolerance using visual analogue scales (VAS) [ Time Frame: 24 hours ]Subjective ratings of bloating, stool consistency, and flatulence on VAS. A stool count was also recorded.
|Study Start Date:||March 2009|
|Study Completion Date:||June 2009|
|Primary Completion Date:||June 2009 (Final data collection date for primary outcome measure)|
Placebo Comparator: Placebo
Treatment without scFOS fiber
Experimental: scFOS 5 g
5 g scFOS
Dietary Supplement: Short chain fructo-oligosaccharide (scFOS) 5 g
Dietary Supplement: scFOS 5 g
Novel fiber administered in two 5 g doses--the first in a beverage and the second in a solid chew.
Other Name: fructo-oligosaccharide
Experimental: scFOS 8 g
8 g scFOS
Dietary Supplement: Short chain fructooligosaccharide (scFOS) 8 g
Novel fiber administered in two 8 g doses--the first in a beverage and the second in a solid chew.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01100788
|United States, Minnesota|
|University of Minnesota|
|Saint Paul, Minnesota, United States, 55108|
|Principal Investigator:||Joanne Slavin||University of Minnesota - Clinical and Translational Science Institute|