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Age Gender Left Ventricular Mass and Cardiac Troponin T

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ClinicalTrials.gov Identifier: NCT01100710
Recruitment Status : Completed
First Posted : April 9, 2010
Last Update Posted : April 9, 2010
Sponsor:
Information provided by:
Heidelberg University

Brief Summary:
The purpose of this study is to determine the influence of functional or anatomic cardiac parameters, age and gender on high sensitivity cTnT (TnThs) levels in healthy individuals.

Condition or disease
Heart Failure

Detailed Description:
We sought to investigate the relative contribution of functional or anatomic parameters as assessed by cardiac magnetic resonance tomography (cMRI, 1.5 Tesla), and clinical variables including increasing age and gender on high sensitivity cTnT (TnThs) levels in healthy individuals. Therefore we measured TnThs in serum samples of 120 healthy volunteers aged between 20 and 70 years. All individuals underwent cMRI including stress testing using dobutamine or adenosine.TnThs concentrations were related to cMRI and clinical findings. Partial correlation, as well as linear and hierarchical regression analyses were used to identify independent predictors and their relative contribution for prediction of TnThs values.

Study Type : Observational
Actual Enrollment : 116 participants
Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Relative Contribution of Age, Gender and Left Ventricular Mass as Quantified by Cardiac Magnetic Resonance Tomography to Detectable Levels of Cardiac Troponin T in a Healthy Reference Population Aged Below 70 Years
Study Start Date : March 2007
Actual Primary Completion Date : March 2007
Actual Study Completion Date : December 2009

Group/Cohort
healthy volunteers




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Ages Eligible for Study:   20 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
residents of Heidelberg and urban hinterland
Criteria

Inclusion Criteria:

  • agreement, age > 18 years, men and women

Exclusion Criteria:

  • measurable heart disease, any chronic or acute disease, intake of meds, hypertension, Diabetes

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01100710


Locations
Germany
University Hospital of Heidelberg
Heidelberg, Baden-Würtemberg, Germany, 69120
Sponsors and Collaborators
Heidelberg University
Investigators
Principal Investigator: Evangelos Giannitsis, Prof.

Publications:
Responsible Party: Prof. Dr. med. E. Giannitsis, University Hospital Heidelberg
ClinicalTrials.gov Identifier: NCT01100710     History of Changes
Other Study ID Numbers: UHD
First Posted: April 9, 2010    Key Record Dates
Last Update Posted: April 9, 2010
Last Verified: February 2007

Keywords provided by Heidelberg University:
Age Gender left ventricular mass high sensitive Troponin T

Additional relevant MeSH terms:
Heart Failure
Heart Diseases
Cardiovascular Diseases