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Age Gender Left Ventricular Mass and Cardiac Troponin T

This study has been completed.
Information provided by:
Heidelberg University Identifier:
First received: April 8, 2010
Last updated: NA
Last verified: February 2007
History: No changes posted
The purpose of this study is to determine the influence of functional or anatomic cardiac parameters, age and gender on high sensitivity cTnT (TnThs) levels in healthy individuals.

Heart Failure

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Relative Contribution of Age, Gender and Left Ventricular Mass as Quantified by Cardiac Magnetic Resonance Tomography to Detectable Levels of Cardiac Troponin T in a Healthy Reference Population Aged Below 70 Years

Further study details as provided by Heidelberg University:

Enrollment: 116
Study Start Date: March 2007
Study Completion Date: December 2009
Primary Completion Date: March 2007 (Final data collection date for primary outcome measure)
healthy volunteers

Detailed Description:
We sought to investigate the relative contribution of functional or anatomic parameters as assessed by cardiac magnetic resonance tomography (cMRI, 1.5 Tesla), and clinical variables including increasing age and gender on high sensitivity cTnT (TnThs) levels in healthy individuals. Therefore we measured TnThs in serum samples of 120 healthy volunteers aged between 20 and 70 years. All individuals underwent cMRI including stress testing using dobutamine or adenosine.TnThs concentrations were related to cMRI and clinical findings. Partial correlation, as well as linear and hierarchical regression analyses were used to identify independent predictors and their relative contribution for prediction of TnThs values.

Ages Eligible for Study:   20 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
residents of Heidelberg and urban hinterland

Inclusion Criteria:

  • agreement, age > 18 years, men and women

Exclusion Criteria:

  • measurable heart disease, any chronic or acute disease, intake of meds, hypertension, Diabetes
  Contacts and Locations
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Please refer to this study by its identifier: NCT01100710

University Hospital of Heidelberg
Heidelberg, Baden-Würtemberg, Germany, 69120
Sponsors and Collaborators
Heidelberg University
Principal Investigator: Evangelos Giannitsis, Prof.
  More Information

Responsible Party: Prof. Dr. med. E. Giannitsis, University Hospital Heidelberg Identifier: NCT01100710     History of Changes
Other Study ID Numbers: UHD
Study First Received: April 8, 2010
Last Updated: April 8, 2010

Keywords provided by Heidelberg University:
Age Gender left ventricular mass high sensitive Troponin T

Additional relevant MeSH terms:
Heart Failure
Heart Diseases
Cardiovascular Diseases processed this record on September 21, 2017