Comparison of 18F-fluorodeoxyglucose Positron Emission Tomography and Coronary Computed Tomography in Assessing Vascular Inflammation

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2010 by Korea University.
Recruitment status was  Recruiting
Information provided by:
Korea University Identifier:
First received: April 8, 2010
Last updated: June 23, 2011
Last verified: March 2010

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.cardiac multidetector-row CT can provide measurements of coronary artery calcium (CAC), the degree of stenosis, and the characteristics of plaque including its potential vulnerability. Therefore, the purpose of the investigators study is to compare the usefulness of 18 FDG-PET and MDCT in assessing the vascular inflammatory status and vulnerability.

Condition Intervention
Other: Cross section study

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Comparison of 18F-fluorodeoxyglucose Positron Emission Tomography and Coronary Computed Tomography in Assessing Vascular Inflammation in Healthy Population

Resource links provided by NLM:

Further study details as provided by Korea University:

Primary Outcome Measures:
  • Correlation between vascular inflammatory status measured by 18FDG PET and MDCT [ Time Frame: 20weeks ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Comparison the correlation with inflammatory marker and vascular inflammatory status assessed by 18FDG PET and MDCT [ Time Frame: 20 weeks ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA

plasam and serum

Estimated Enrollment: 120
Study Start Date: April 2010
Estimated Study Completion Date: August 2011
Estimated Primary Completion Date: July 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Healthy patients Other: Cross section study
This is not intervention study. The purpose of the study is to examine the relationship of vascular inflammation assessed by 18FDG-PET and MDCT at the cross section setting


Ages Eligible for Study:   20 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Healthy participants who underwent a medical health check in the health promotion center in Korea Guro University


Inclusion Criteria:

  • Healthy patients for visiting routine medical check in our clinic

Exclusion Criteria:

  • History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
  • Diabetes
  • Stage 2 hypertension (resting blood pressure, ≥ 160/100 mmHg)
  • Malignancy
  • Severe renal or hepatic disease
  • Subjects taking medications that might affect inflammation such as NSIAD and statin
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01100671

Contact: Hye Jin Yoo, MD 82-2-2626-3045

Korea, Republic of
Hye Jin Yoo Recruiting
Seoul, Korea, Republic of
Contact: Hye Jin Yoo, MD.PhD    82226263045   
Contact: Kyung Mook Choi, MD.PhD    82226263043   
Sponsors and Collaborators
Korea University
Principal Investigator: Kyung Mook Choi, MD.PhD Korea University
  More Information

No publications provided

Responsible Party: Kyung Mook Choi, Korea University Identifier: NCT01100671     History of Changes
Other Study ID Numbers: PET_Coronary CT
Study First Received: April 8, 2010
Last Updated: June 23, 2011
Health Authority: South Korea: Institutional Review Board

Keywords provided by Korea University:
vascular inflammation

Additional relevant MeSH terms:
Arterial Occlusive Diseases
Cardiovascular Diseases
Pathologic Processes
Vascular Diseases
Fluorodeoxyglucose F18
Diagnostic Uses of Chemicals
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Radiopharmaceuticals processed this record on October 09, 2015