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Comparison of 18F-fluorodeoxyglucose Positron Emission Tomography and Coronary Computed Tomography in Assessing Vascular Inflammation

This study has been completed.
Information provided by (Responsible Party):
Kyung Mook Choi, Korea University Identifier:
First received: April 8, 2010
Last updated: October 12, 2015
Last verified: March 2010
Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.cardiac multidetector-row CT can provide measurements of coronary artery calcium (CAC), the degree of stenosis, and the characteristics of plaque including its potential vulnerability. Therefore, the purpose of the investigators study is to compare the usefulness of 18 FDG-PET and MDCT in assessing the vascular inflammatory status and vulnerability.

Condition Intervention
Other: Cross section study

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Comparison of 18F-fluorodeoxyglucose Positron Emission Tomography and Coronary Computed Tomography in Assessing Vascular Inflammation in Healthy Population

Resource links provided by NLM:

Further study details as provided by Korea University:

Primary Outcome Measures:
  • Correlation between vascular inflammatory status measured by 18FDG PET and MDCT [ Time Frame: 20weeks ]

Secondary Outcome Measures:
  • Comparison the correlation with inflammatory marker and vascular inflammatory status assessed by 18FDG PET and MDCT [ Time Frame: 20 weeks ]

Biospecimen Retention:   Samples Without DNA
plasam and serum

Enrollment: 120
Study Start Date: April 2010
Study Completion Date: August 2011
Primary Completion Date: July 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Healthy patients Other: Cross section study
This is not intervention study. The purpose of the study is to examine the relationship of vascular inflammation assessed by 18FDG-PET and MDCT at the cross section setting


Ages Eligible for Study:   20 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy participants who underwent a medical health check in the health promotion center in Korea Guro University

Inclusion Criteria:

  • Healthy patients for visiting routine medical check in our clinic

Exclusion Criteria:

  • History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
  • Diabetes
  • Stage 2 hypertension (resting blood pressure, ≥ 160/100 mmHg)
  • Malignancy
  • Severe renal or hepatic disease
  • Subjects taking medications that might affect inflammation such as NSIAD and statin
  Contacts and Locations
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Please refer to this study by its identifier: NCT01100671

Korea, Republic of
Hye Jin Yoo
Seoul, Korea, Republic of
Sponsors and Collaborators
Korea University
Principal Investigator: Kyung Mook Choi, MD.PhD Korea University
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Kyung Mook Choi, Professor, Korea University Identifier: NCT01100671     History of Changes
Other Study ID Numbers: PET_Coronary CT
Study First Received: April 8, 2010
Last Updated: October 12, 2015

Keywords provided by Korea University:
vascular inflammation

Additional relevant MeSH terms:
Pathologic Processes
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases
Fluorodeoxyglucose F18
Molecular Mechanisms of Pharmacological Action
Antiviral Agents
Anti-Infective Agents
Radiopharmaceuticals processed this record on May 23, 2017