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Prefrontal Cortex and Abstract Thinking

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01100281
First Posted: April 8, 2010
Last Update Posted: December 9, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Institut National de la Santé Et de la Recherche Médicale, France
  Purpose

The capacity of concept formation is not well understood, even if a link is supposed with the functioning of the frontal lobes.

Our aim is to better understand the cognitive mechanisms underlying this function and to try to correlate the performance with atrophy of the frontal lobe in neurodegenerative diseases involving this region (frontotemporal lobar degeneration and progressive supranuclear palsy).


Condition Intervention
Abstract Thinking Concept Formation Behavioral: Neuropsychological examination Other: MRI

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Neuropsychological and Anatomical Study of Concept Formation in Frontal Patients

Further study details as provided by Institut National de la Santé Et de la Recherche Médicale, France:

Enrollment: 69
Study Start Date: April 2010
Study Completion Date: April 2011
Groups/Cohorts Assigned Interventions
PSP (Progressive supranuclear palsy) Behavioral: Neuropsychological examination
Examination including especially concept formation
Other: MRI
MRI performed in T1-weighted three dimensional sequence
FTD (Frontotemporal lobar degenerative) Behavioral: Neuropsychological examination
Examination including especially concept formation
Other: MRI
MRI performed in T1-weighted three dimensional sequence
Alzheimer's disease Behavioral: Neuropsychological examination
Examination including especially concept formation
Other: MRI
MRI performed in T1-weighted three dimensional sequence

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
3 groups including : PSP, FTD, AD
Criteria

Inclusion Criteria:

  • informed consent signed
  • MMSE> 20
  • No contra indication to MRI

Exclusion Criteria:

  • MMSE<20
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01100281


Locations
France
Inserm U 975
Paris, France, 75013
Sponsors and Collaborators
Institut National de la Santé Et de la Recherche Médicale, France
Investigators
Study Director: Richard Levy, MD Institut National de la Santé Et de la Recherche Médicale, France
  More Information

Responsible Party: Institut National de la Santé Et de la Recherche Médicale, France
ClinicalTrials.gov Identifier: NCT01100281     History of Changes
Other Study ID Numbers: C09-29
First Submitted: April 7, 2010
First Posted: April 8, 2010
Last Update Posted: December 9, 2011
Last Verified: December 2011

Keywords provided by Institut National de la Santé Et de la Recherche Médicale, France:
prefrontal cortex