Cardiac Magnetic Resonance Imaging and Pulmonary Perfusion
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|ClinicalTrials.gov Identifier: NCT01100008|
Recruitment Status : Completed
First Posted : April 8, 2010
Last Update Posted : March 14, 2016
Pulmonary hypertension is a rare severe disease leading to cardiac insufficiency. Treatment depends on the severity of the disease.
This study evaluates cardiac MRI for the assessment of pulmonary hypertension severity and identification of parameters useful for the follow-up in order to adapt the medical treatment to status of the patient.
Evaluate if cardiac MRI can obviate right cardiac catheterization in the follow-up.
|Condition or disease||Intervention/treatment||Phase|
|Pulmonary Hypertension||Procedure: Magnetic resonance imaging (MRI)||Not Applicable|
Thirty patients will be enrolled and followed for 1 year after their inclusion.
Cardiac MRI will be performed at inclusion and at 3 months and 12 months. At the same periods, echocardiography and right heart catheterization will be performed too.
Morphological and functional parameters will be studied with MRI and correlated to invasive parameters and echocardiography too.
Morphological parameters are: volumes, cardiac cavities areas and ratios and position of the interventricular septum. Functional parameters are: ejection fractions of right and left cavities, flow in pulmonary artery, across mitral and tricuspid valves, temporal measurements in the pulmonary artery and auriculoventricular valves.
The invasive measurements are considered as the gold standard for this study. The classification of the severity is defined according to the parameters from right cardiac catheterization (4 grades with severity increasing between 1 and 4).
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||29 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Cardiac Magnetic Resonance Imaging and Pulmonary Perfusion: Its Role in the Diagnosis of the Severity of Pulmonary Hypertension in Adults and in the Follow-up. Preliminary Study.|
|Study Start Date :||September 2007|
|Actual Primary Completion Date :||September 2013|
|Actual Study Completion Date :||June 2014|
|Experimental: Magnetic resonance imaging||
Procedure: Magnetic resonance imaging (MRI)
MRI cardiac and pulmonary with gadolinium
- Nuclear magnetic resonance imaging [ Time Frame: Inclusion ; 3rd month ; 12th month ]Correlation of cardiac results from the first MRI (Magnetic Resonance Imaging) to invasive measurements from the first or initial right heart catheterization and to echocardiography to know if cardiac MRI is able to predict severity of the disease
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01100008
|Service de radiologie - Hôpital Rangueil|
|Toulouse, Midi-Pyrénées, France, 31000|
|Principal Investigator:||Valérie Chabbert, MD||University Hospital, Toulouse|