Apoptotic Cell (AC) Uptake by Human Alveolar Macrophages (AM)
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|ClinicalTrials.gov Identifier: NCT01099410|
Recruitment Status : Completed
First Posted : April 7, 2010
Last Update Posted : January 6, 2016
|Condition or disease||Intervention/treatment|
|Chronic Obstructive Pulmonary Disease||Procedure: Fiberoptic bronchoscopy Procedure: blood draw Procedure: intravenous catheter|
|Study Type :||Observational|
|Actual Enrollment :||17 participants|
|Official Title:||Apoptotic Cell Ingestion by Normal Human Alveolar Macrophages|
|Study Start Date :||February 2010|
|Actual Primary Completion Date :||June 2015|
|Actual Study Completion Date :||December 2015|
Procedure: Fiberoptic bronchoscopy
which a flexible video instrument is passed via the nose or mouth, through the vocal cords and into the lungs. During the procedure, portions of the lungs will be washed ("lavaged") with a salt water solution, to collect the alveolar macrophages. This procedure involves conscious sedation, so that a driver is required on the day of the bronchoscopy. The entire procedure, including placement of an intravenous line to administer medications, local anesthetics, the bronchoscopy itself, and the recovery period, takes about 2.5-3 hours.
Procedure: blood draw
Blood will be collected at the enrollment visit to test the subject to exclude disorders that would make it unsafe to perform the bronchoscopy, including severe anemia, infection, or disorders of kidney or liver function.
Procedure: intravenous catheter
An intravenous catheter is placed on the day of the bronchoscopy to permit administration of sedative medications.
Other Name: IV
- macrophage uptake of apoptotic cells in vitro [ Time Frame: 1-7 days ]
- spirometric measurement of lung function [ Time Frame: 1-30 days ]
Biospecimen Retention: None Retained
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01099410
|United States, Michigan|
|VA Ann Arbor Healthcare System, Ann Arbor, MI|
|Ann Arbor, Michigan, United States, 48105|
|Principal Investigator:||Jeffrey L Curtis, MD||VA Ann Arbor Healthcare System, Ann Arbor, MI|