Transcranial Magnetic Stimulation of the Prefrontal Cortex: Effects on Risky Decision Making and Temporal Discounting.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01098864
Recruitment Status : Withdrawn (Study was withdrawn prior to the first subject being enrolled due to the Co-Investigator leaving the university)
First Posted : April 5, 2010
Last Update Posted : March 4, 2015
Information provided by:
University of Arkansas

Brief Summary:
The main objective of this study is to examine the effects of magnetic stimulation on the prefrontal cortex. We plan to use low frequency, repeated transcranial magnetic stimulation (1 Hz rTMS) to temporarily inhibit activity in the prefrontal cortex and measure the resulting effect on two decision-making tasks. The prefrontal cortex is thought to mediate or control cognitive functions like decision-making, planning, memory, and inhibit impulsive behavior.Previous research has indicated that rTMS over the right dorsal lateral prefrontal cortex will lead to preferences for riskier alternatives. Our hypothesis is that rTMS over the right DLPFC will lead to greater preference for the riskier alternative and greater temporal discounting.

Condition or disease Intervention/treatment Phase
Decision Making Device: transcranial magnetic stimulation Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 0 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Official Title: Transcranial Magnetic Stimulation of the Prefrontal Cortex: Effects on Risky Decision Making and Temporal Discounting.
Study Start Date : May 2011
Estimated Primary Completion Date : January 2014
Estimated Study Completion Date : January 2014

Intervention Details:
  • Device: transcranial magnetic stimulation
    low frequency (1 Hz) repeated transcranial magnetic stimulation will be delivered to the dorsal lateral prefrontal cortex (DLPFC) area for a period of 15 minutes to test for effect on executive function (e.g., decision choice and subjective value). Four sessions will be conducted per subject; 2 active stimulations,(1 left DLPFC, 1 right DLPFC) and 2 sham stimulations (1 left DLPFC, 1 right DLPFC) with a minimum of 48 hours between every stimulation. Pre and post stimulations measures of cognitive and executive function will be collected and analyzed for significant differences.
    Other Name: Magstim Super Rapid 2 Stimulator w/ 70mm figure eight stimulating coil

Primary Outcome Measures :
  1. The k metric of a hyperbolic function for delayed discounting [ Time Frame: 12-18 weeks ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy participants willing to give informed consent to participate
  • complete the Transcranial magnetic stimulation Adult Safety Screen
  • have a MRI scan
  • wear ear plugs during rTMS
  • receive rTMS over the designated course of days
  • complete cognitive assessments and decision making tasks.
  • return for post-testing on all tasks after completing all rTMS sessions

Exclusion Criteria:

  • Diagnosed neurological and/or psychiatric disorders requiring hospitalization or medication
  • pregnancy or the possibility of pregnancy at the time of consent
  • a history of tinnitus
  • metal implants in head or neck or a pacemaker
  • poorly-controlled migraines
  • a history of head injury, stroke, previous brain neurosurgery, or loss of consciousness due to head injury lasting greater than 10 minutes
  • a personal or family history of epilepsy or seizures

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01098864

Sponsors and Collaborators
University of Arkansas
Principal Investigator: Mark S Mennemeier, PhD Universtiy of Arkansas for Medical Sciences

Responsible Party: Mark Mennemeier, PhD / Principal Investigator, UAMS Identifier: NCT01098864     History of Changes
Other Study ID Numbers: 109639
First Posted: April 5, 2010    Key Record Dates
Last Update Posted: March 4, 2015
Last Verified: March 2015

Keywords provided by University of Arkansas:
Transcranial Magnetic Stimulation