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Effects Of Unilateral Vibration On Contralateral Forearm Muscle Activity (BMRR3)

This study has been completed.
Information provided by (Responsible Party):
ILHAN KARACAN, Vakif Gureba Training and Research Hospital Identifier:
First received: March 27, 2010
Last updated: February 24, 2012
Last verified: February 2012

This study hypothesize that radius subjecting to mechanical loading may affect excitability of alpha motor neuron innervating muscle, based on its bone mineral density or bone mineral content.

A total of 80 voluntaries are planned to include in this study. Vibration will be applied the right forearm. Muscle electrical activity will be measured on ipsilateral and contralateral flexor carpi radialis (FCR) muscle at rest as EMGrms by surface electromyography (EMG). The rest-EMGrms will be measured at before and during vibration. An increase in muscle electrical activity at rest indicates an increase in motor neuron pool activation. The right distal radius bone mineral content (BMC) and density will be measured by dual energy X-ray absorptiometry (DXA).

The right radius bone mineral density (BMD) and BMC will be evaluated by bone densitometer (GE-LUNAR DPX PRO).

Motor unit potentials will be measured by electromyography at left flexor carpi radialis. Neurotrac ETS device will be used.

Condition Intervention
Procedure: Forearm vibration

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Double Blind (Participant, Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: Effects Of Unilateral Forearm Vibration On Electrical Activity Of Untrained Contralateral Forearm Muscle

Further study details as provided by Vakif Gureba Training and Research Hospital:

Primary Outcome Measures:
  • Changes in rest muscle electrical activity in the contralateral untrained flexor carpi radialis during the right forearm vibration [ Time Frame: 2 or 3 weeks ]
    Rest muscle electrical activity changes will be examined in the contralateral untrained flexor carpi radialis during the right forearm vibration

Enrollment: 90
Study Start Date: March 2010
Study Completion Date: July 2010
Primary Completion Date: June 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Healthy young adult subjects
Forearm vibration will be applied in healthy young adult subjects
Procedure: Forearm vibration
Mechanical loading with forearm vibration will be applied right radius in all groups
Other Name: Cyclic mechanical loading

Detailed Description:

A functional cooperation exists between bones and skeletal muscles. Bones work together with muscles as a simple mechanical lever system to produce body movement. One of the important functions of bones is to exert resistance against gravity in order to carry the body. In order to carry out their mechanical functions, bones need to have considerable resistance to deformation under load. It is well-known that muscle activity (i.e., exercises) improves the resistance of bone to mechanical loading, and that it is also important for treating and preventing osteoporosis. Resistance and impact training have been shown to induce bone formation and/or prevent bone resorption. Skeletal muscles have positive effects on bone structure and function. Can bones have an effect on muscle activity? There is only one study about the effect of bones on muscles. In this study, it was shown that bones may affect muscle strength gain in healthy young adult males.

Vibration has a strong osteogenic effect. Vibration-induced bone formation is neuronally regulated. Vibration can also effectively enhance muscle strength and power. Previous studies have shown that vibration increases muscle electromyographic (EMG) activity. But, it has not been reported whether bone has an effect on the increase in muscle EMG activity caused by vibration or not. The aim of this study was to determine whether radius bone exposed to cyclic mechanical loading affects muscle electrical activity of contralateral untrained m. flexor carpi radialis in healthy adult volunteers.


Ages Eligible for Study:   20 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy subjects
  • Right handed
  • Young adult women and men

Exclusion Criteria:

  • secondary osteoporosis
  • neuropathy (central or peripheral)
  • myopathy
  • systemic diseases (arthritis, endocrine-metabolic diseases, bone diseases)
  • professional sportswoman/sportsman
  • subjects doing regular sports activities
  • tendinopathy
  • amputee, endoprosthesis, metal implants
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Please refer to this study by its identifier: NCT01097122

Vakif Gureba Training & Research Hospital
İstanbul, Turkey, 34000
Sponsors and Collaborators
Vakif Gureba Training and Research Hospital
Study Chair: ILHAN KARACAN, MD Vakif Gureba Training & Research Hospital
  More Information

Responsible Party: ILHAN KARACAN, Vakif Gureba Training and Research Hospital Identifier: NCT01097122     History of Changes
Other Study ID Numbers: VGEAH FTR-3
Study First Received: March 27, 2010
Last Updated: February 24, 2012

Keywords provided by Vakif Gureba Training and Research Hospital:
motor neuron excitability
forearm vibration
mechanical loading
muscle electrical activity

Additional relevant MeSH terms:
Bone Diseases, Metabolic
Bone Diseases
Musculoskeletal Diseases processed this record on May 22, 2017