Etiology of Uncomplicated Fever in Children <5 in Rural Zanzibar (RDTNEG)
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01094431
Recruitment Status :
First Posted : March 29, 2010
Last Update Posted : December 3, 2014
Karolinska University Hospital
Zanzibar Malaria Control Programme
World Health Organization
Queen Silvia Children's Hospital, Gothenburg, Sweden
The purpose of this study is to study the most common etiologies of uncomplicated fever diseases among children under five years of age in rural Zanzibar.
Condition or disease
During the last 6 years Zanzibar has undergone a dramatic change in malaria epidemiology and burden of disease, with a marked decline of Plasmodium falciparum malaria among febrile children from approximately 30% to 1% or below and a reduction of crude child mortality of 50%. Millions of children in Africa die of neonatal disorders, acute respiratory tract infections (ARI), diarrhea, malaria, measles, HIV and malnutrition. A majority of these illnesses are also a common cause of febrile illness in out-patient departments. However, most of the few fever studies made in Africa are hospital based Very few studies on etiology of childhood febrile disease have been conducted on first level health facilities in the least developed countries in Africa. This study will therefore focus on children between 2 months to 5 years of age that have been diagnosed with a negative rapid diagnostic test (RDT) for malaria and their causes of fever at the first referral level in out-patient clinics in Zanzibar.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study:
2 Months to 59 Months (Child)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Kivunge Primary Health Care Center (PHCC) in North A District in Zanzibar
Patients between 2-59 months of age with confirmed fever, with a measured axillary temperature of ≥37.5˚C, or history of fever within the preceding 24 hours.
Presenting at the health facility from 8.00 to 16.00 Monday to Friday.
Able and willing to complete stipulated follow-up.
Decision by the clinician to refer the patient to another health facility than the PHCC where the study is conducted.
Symptoms/ signs of severe disease that requires immediate referral from the PHCC as defined by the clinicians. These symptoms/signs of severe disease are according to the IMCI guidelines.