Diurnal Variation of Mineral Metabolism and Protein Fermentation Metabolites in Peritoneal Dialysis Patients and Healthy Volunteers
Many epidemiological studies have pointed to the association between serum parameters of phosphate metabolism (phosphate, FGF23) and microbiotic protein fermentation (p-cresyl sulphate [PCS], indoxyl sulphate [IS]) on the one hand and increased risk of all-cause and cardiovascular death on the other hand.
Hypothesis: Due to failing feed-back mechanisms, diurnal variation of serum concentrations of serum phosphate and fermentation metabolites will be more pronounced in dialysis patients, especially in those with negligible residual kidney function.
Clinical studies assessing this issue are scarce to non-existing.
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Diurnal Variation of Mineral Metabolism and Protein Fermentation Metabolites in Peritoneal Dialysis Patients and Healthy Volunteers|
- To evaluate the diurnal variation of serum concentrations of phosphate and protein fermentation metabolites in healthy volunteers as compared to dialysis patients. [ Time Frame: 4 months ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
whole blood, serum, urine and dialysate
|Study Start Date:||February 2010|
|Estimated Study Completion Date:||December 2014|
|Estimated Primary Completion Date:||December 2014 (Final data collection date for primary outcome measure)|
patients on peritoneal dialysis
Please refer to this study by its ClinicalTrials.gov identifier: NCT01093456
|Contact: Pieter Evenepoel, MD, PhDemail@example.com|
|Leuven, Vlaams-Brabant, Belgium, 3000|
|Contact: Pieter Evenepoel, MD, PhD 003216344580 firstname.lastname@example.org|
|Principal Investigator: Pieter Evenepoel, MD,PhD|