Diurnal Variation of Uremic Solutes in Peritoneal Dialysis
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|ClinicalTrials.gov Identifier: NCT01093456|
Recruitment Status : Completed
First Posted : March 25, 2010
Last Update Posted : May 13, 2016
|Condition or disease|
|Chronic Kidney Disease|
Many epidemiological studies have pointed to the association between serum parameters of phosphate metabolism (phosphate, FGF23) and microbiotic protein fermentation (p-cresyl sulphate [PCS], indoxyl sulphate [IS]) on the one hand and increased risk of all-cause and cardiovascular death on the other hand.
Hypothesis: Due to failing feed-back mechanisms, diurnal variation of serum concentrations of serum phosphate and fermentation metabolites will be more pronounced in dialysis patients, especially in those with negligible residual kidney function.
Clinical studies assessing this issue are scarce to non-existing.
|Study Type :||Observational|
|Actual Enrollment :||18 participants|
|Observational Model:||Case Control|
|Official Title:||Diurnal Variation of Mineral Metabolism and Protein Fermentation Metabolites in Peritoneal Dialysis Patients and Healthy Volunteers|
|Study Start Date :||February 2010|
|Primary Completion Date :||December 2012|
|Study Completion Date :||December 2012|
chronic kidney disease
ESKD patients treated with peritoneal dialysis
healthy volunteers, aged 18 years and above
- To evaluate the diurnal variation of serum concentrations of phosphate and protein fermentation metabolites in healthy volunteers as compared to dialysis patients. [ Time Frame: 4 months ]
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01093456
|Leuven, Vlaams-Brabant, Belgium, 3000|
|Principal Investigator:||Pieter Evenepoel, MD, PhD||UZ Leuven|