2D and Tissue Doppler Imaging Echocardiography Analysis of Left Ventricular Regional Wall Motion and Prognosis (TDI)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01092429
Recruitment Status : Unknown
Verified June 2011 by Chang Gung Memorial Hospital.
Recruitment status was:  Recruiting
First Posted : March 25, 2010
Last Update Posted : July 29, 2014
Information provided by (Responsible Party):
Chang Gung Memorial Hospital

Brief Summary:

Development of myocardial ischemia, and/or myocarditis would induce different changes in myocardial contraction behavior pattern,which maybe very subtle, and may not be detected by the 2D and m-mode echocardiography examinations. According to tissue Doppler imaging(TDI), they can be depicted by different models of echo with higher frame rates. In addition, many studies using TDI have significantly contributed of efforts to evaluate systolic and diastolic function and prognosis.

This study assess the value of the indices of left ventricular function obtained by using TDI in patient with coronary artery disease(CAD). We hypothesized that TDI will add incremental value for regional wall motion abnormality of CAD and its prognosis.

Condition or disease
Coronary Artery Disease

Study Type : Observational
Estimated Enrollment : 500 participants
Observational Model: Cohort
Time Perspective: Prospective
Study Start Date : February 2008
Estimated Primary Completion Date : December 2015
Estimated Study Completion Date : December 2015

Resource links provided by the National Library of Medicine

one,two,and three vessels disease; mortality

Primary Outcome Measures :
  1. all cause mortality [ Time Frame: one year ]

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Accoring to recommendation of ACC/AHA, patient had classI indication to perform coronary angiography

Inclusion Criteria:

  1. Angina
  2. Acue coronary syndrome
  3. Left ventricular systolic dysfunction

Exclusion Criteria:

  1. Significant valvular disease
  2. Active cancer status
  3. Acute Renal failure
  4. Contrast allergy history
  5. Pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01092429

Contact: Fun-Chung Lin, MD

Cheng Gung Memorial Hospital at Linkou Recruiting
Taipei, Taiwan
Contact: Tsang-Tang Hsieh, MD    +886 -3-3196200 ext 3656   
Sponsors and Collaborators
Chang Gung Memorial Hospital

Responsible Party: Chang Gung Memorial Hospital Identifier: NCT01092429     History of Changes
Other Study ID Numbers: 96-1504B
First Posted: March 25, 2010    Key Record Dates
Last Update Posted: July 29, 2014
Last Verified: June 2011

Keywords provided by Chang Gung Memorial Hospital:

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases