Prevalence Of Microalbuminuria Among Children Suffering From Sickle Cell Nephropathy and Sickle Cell/Beta-Thalassemia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01092169
Recruitment Status : Unknown
Verified March 2010 by Hillel Yaffe Medical Center.
Recruitment status was:  Not yet recruiting
First Posted : March 24, 2010
Last Update Posted : March 24, 2010
Information provided by:
Hillel Yaffe Medical Center

Brief Summary:

Sickle cell nephropathy is a known complication of sickle cell anemia (SCA) manifested by increase in glomerular filtration rate (glomerular hyperfiltration) and results in proteinuria and chronic renal failure.

Our goal is to examine the prevalence of proteinuria and microalbuminuria as an early predictive factor of glomerular injury, among young people who suffer from SCA as well as those who suffer from combined sickle cell/beta-thalassemia.

Condition or disease Intervention/treatment
Sickle Cell Anemia Beta-Thalassemia Microalbuminuria Other: No intervention

Study Type : Observational
Observational Model: Cohort
Time Perspective: Cross-Sectional

Group/Cohort Intervention/treatment
Sickle cell beta Other: No intervention

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Ages Eligible for Study:   up to 25 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Young people suffering from SCA as well as those who suffer from combined sickle cell/beta-thalassemia, between 0-25 years old.

Inclusion Criteria:

  • Patients diagnosed with sickle cell anemia
  • Patients diagnosed with combined sickle cell anemia/beta-thalassemia

Exclusion Criteria:

  • Diabetes mellitus
  • Hypertension
  • Reduced renal mass (single kidney)
  • Overweight
  • History of UTIs

Responsible Party: Amit Hochberg, Pediatrics Department, Hillel Yaffe Medical Center Identifier: NCT01092169     History of Changes
Other Study ID Numbers: 64/2009
First Posted: March 24, 2010    Key Record Dates
Last Update Posted: March 24, 2010
Last Verified: March 2010

Additional relevant MeSH terms:
Anemia, Sickle Cell
Anemia, Hemolytic, Congenital
Anemia, Hemolytic
Hematologic Diseases
Genetic Diseases, Inborn