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Prevalence Of Microalbuminuria Among Children Suffering From Sickle Cell Nephropathy and Sickle Cell/Beta-Thalassemia

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2010 by Hillel Yaffe Medical Center.
Recruitment status was:  Not yet recruiting
Information provided by:
Hillel Yaffe Medical Center Identifier:
First received: March 23, 2010
Last updated: NA
Last verified: March 2010
History: No changes posted

Sickle cell nephropathy is a known complication of sickle cell anemia (SCA) manifested by increase in glomerular filtration rate (glomerular hyperfiltration) and results in proteinuria and chronic renal failure.

Our goal is to examine the prevalence of proteinuria and microalbuminuria as an early predictive factor of glomerular injury, among young people who suffer from SCA as well as those who suffer from combined sickle cell/beta-thalassemia.

Condition Intervention
Sickle Cell Anemia Beta-Thalassemia Microalbuminuria Other: No intervention

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional

Resource links provided by NLM:

Further study details as provided by Hillel Yaffe Medical Center:

Groups/Cohorts Assigned Interventions
Sickle cell beta Other: No intervention


Ages Eligible for Study:   up to 25 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Young people suffering from SCA as well as those who suffer from combined sickle cell/beta-thalassemia, between 0-25 years old.

Inclusion Criteria:

  • Patients diagnosed with sickle cell anemia
  • Patients diagnosed with combined sickle cell anemia/beta-thalassemia

Exclusion Criteria:

  • Diabetes mellitus
  • Hypertension
  • Reduced renal mass (single kidney)
  • Overweight
  • History of UTIs
  Contacts and Locations
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No Contacts or Locations Provided
  More Information

Responsible Party: Amit Hochberg, Pediatrics Department, Hillel Yaffe Medical Center Identifier: NCT01092169     History of Changes
Other Study ID Numbers: 64/2009
Study First Received: March 23, 2010
Last Updated: March 23, 2010

Additional relevant MeSH terms:
Anemia, Sickle Cell
Anemia, Hemolytic, Congenital
Anemia, Hemolytic
Hematologic Diseases
Genetic Diseases, Inborn processed this record on September 21, 2017