Study of Effects of L-Arginine in Colitis and Colon Cancer
The purpose of this study is to look at the importance of L-Arginine in the digestive tract. L-Arginine is an amino acid and is important in making proteins within the cell.
The evaluation of colon tissue, blood, urine, diet, health history, and symptoms will help us learn more about L-Arginine and ulcerative colitis. The investigators believe these studies will provide new insights into the treatment for Inflammatory Bowel Disease (ulcerative colitis) and nutritional needs. The investigators plan to enroll 200 participants in this study over the next two years.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Immunomodulary Effects of Arginine Supplementation in Colitis and Colon Cancer|
- L-Arginine (L-Arg) availability in ulcerative colitis (UC) patients and normal control subjects, and correlate with disease activity [ Time Frame: 24 months ] [ Designated as safety issue: No ]
- L-Arg intake in the diet of UC patients and control subjects [ Time Frame: 24 months ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
blood, urine and tissue
|Study Start Date:||September 2009|
|Primary Completion Date:||September 2011 (Final data collection date for primary outcome measure)|
Healthy volunteer who is having a screening colonoscopy
Patients with confirmed ulcerative colitis who are scheduled for endoscopy for medical reasons.
Amino acids are being measured in colon tissues and in serum by HPLC. Cytokines and chemokines are being measured in colon tissues and in serum by Luminex assay. Cytokines and chemokines are also being measured in colon tissues by real-time PCR analysis of mRNA expression.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01091558
|United States, Tennessee|
|Nashville, Tennessee, United States, 37232|
|Principal Investigator:||Keith Wilson, MD, AGAF||Vanderbilt University|