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Autologous Serum Skin Test and Serum IL-18 Levels in Chronic Idiopathic Urticaria and Respiratory Allergic Diseases

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01091402
First Posted: March 24, 2010
Last Update Posted: March 24, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Eskisehir Osmangazi University
  Purpose
One of the proposed mechanisms in CU is autoimmunity. It was shown by a positive response to autologous serum skin test (ASST)in almost half of chronic urticaria (CU) patients. IL-18 also play a role in autoimmune disorders. The investigators aim was to investigate the relationship of ASST and IL-18 in CU and respiratory allergic diseases.

Condition Intervention
Urticaria Respiratory Allergic Diseases Procedure: autologous serum skin test, serum IL-18

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Resource links provided by NLM:


Further study details as provided by Eskisehir Osmangazi University:

Study Start Date: January 2009
Groups/Cohorts Assigned Interventions
chronic urticaria Procedure: autologous serum skin test, serum IL-18
asthma Procedure: autologous serum skin test, serum IL-18
seasonal allergic rhinitis Procedure: autologous serum skin test, serum IL-18
normal controls Procedure: autologous serum skin test, serum IL-18

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
patients from Outpatient clinic
Criteria

Inclusion Criteria:

  • adult patients
  • chronic urticaria patients
  • stable asthma patients
  • allergic rhinitis patients with sensitized to pollens
  • normal controls without atopic and skin disease.

Exclusion Criteria:

  • unwillingness to the study
  • other dermatological problems that could affect the skin test
  • use of antihistamine drugs
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01091402


Locations
Turkey
Eskisehir Osmangazi University
Eskisehir, Turkey, 26040
Sponsors and Collaborators
Eskisehir Osmangazi University
  More Information

ClinicalTrials.gov Identifier: NCT01091402     History of Changes
Other Study ID Numbers: 1
First Submitted: March 23, 2010
First Posted: March 24, 2010
Last Update Posted: March 24, 2010
Last Verified: January 2009

Keywords provided by Eskisehir Osmangazi University:
autologous serum skin test, IL-18

Additional relevant MeSH terms:
Urticaria
Skin Diseases, Vascular
Skin Diseases
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases