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Autologous Serum Skin Test and Serum IL-18 Levels in Chronic Idiopathic Urticaria and Respiratory Allergic Diseases

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ClinicalTrials.gov Identifier: NCT01091402
Recruitment Status : Completed
First Posted : March 24, 2010
Last Update Posted : March 24, 2010
Sponsor:
Information provided by:
Eskisehir Osmangazi University

Brief Summary:
One of the proposed mechanisms in CU is autoimmunity. It was shown by a positive response to autologous serum skin test (ASST)in almost half of chronic urticaria (CU) patients. IL-18 also play a role in autoimmune disorders. The investigators aim was to investigate the relationship of ASST and IL-18 in CU and respiratory allergic diseases.

Condition or disease Intervention/treatment
Urticaria Respiratory Allergic Diseases Procedure: autologous serum skin test, serum IL-18

Study Type : Observational
Observational Model: Case Control
Time Perspective: Prospective
Study Start Date : January 2009

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Hives
U.S. FDA Resources

Group/Cohort Intervention/treatment
chronic urticaria Procedure: autologous serum skin test, serum IL-18
asthma Procedure: autologous serum skin test, serum IL-18
seasonal allergic rhinitis Procedure: autologous serum skin test, serum IL-18
normal controls Procedure: autologous serum skin test, serum IL-18




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Ages Eligible for Study:   16 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
patients from Outpatient clinic
Criteria

Inclusion Criteria:

  • adult patients
  • chronic urticaria patients
  • stable asthma patients
  • allergic rhinitis patients with sensitized to pollens
  • normal controls without atopic and skin disease.

Exclusion Criteria:

  • unwillingness to the study
  • other dermatological problems that could affect the skin test
  • use of antihistamine drugs

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01091402


Locations
Turkey
Eskisehir Osmangazi University
Eskisehir, Turkey, 26040
Sponsors and Collaborators
Eskisehir Osmangazi University

ClinicalTrials.gov Identifier: NCT01091402     History of Changes
Other Study ID Numbers: 1
First Posted: March 24, 2010    Key Record Dates
Last Update Posted: March 24, 2010
Last Verified: January 2009

Keywords provided by Eskisehir Osmangazi University:
autologous serum skin test, IL-18

Additional relevant MeSH terms:
Urticaria
Skin Diseases, Vascular
Skin Diseases
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases