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Autologous Serum Skin Test and Serum IL-18 Levels in Chronic Idiopathic Urticaria and Respiratory Allergic Diseases

This study has been completed.
Information provided by:
Eskisehir Osmangazi University Identifier:
First received: March 23, 2010
Last updated: NA
Last verified: January 2009
History: No changes posted
One of the proposed mechanisms in CU is autoimmunity. It was shown by a positive response to autologous serum skin test (ASST)in almost half of chronic urticaria (CU) patients. IL-18 also play a role in autoimmune disorders. The investigators aim was to investigate the relationship of ASST and IL-18 in CU and respiratory allergic diseases.

Condition Intervention
Respiratory Allergic Diseases
Procedure: autologous serum skin test, serum IL-18

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by Eskisehir Osmangazi University:

Study Start Date: January 2009
Groups/Cohorts Assigned Interventions
chronic urticaria Procedure: autologous serum skin test, serum IL-18
asthma Procedure: autologous serum skin test, serum IL-18
seasonal allergic rhinitis Procedure: autologous serum skin test, serum IL-18
normal controls Procedure: autologous serum skin test, serum IL-18


Ages Eligible for Study:   16 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
patients from Outpatient clinic

Inclusion Criteria:

  • adult patients
  • chronic urticaria patients
  • stable asthma patients
  • allergic rhinitis patients with sensitized to pollens
  • normal controls without atopic and skin disease.

Exclusion Criteria:

  • unwillingness to the study
  • other dermatological problems that could affect the skin test
  • use of antihistamine drugs
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Please refer to this study by its identifier: NCT01091402

Eskisehir Osmangazi University
Eskisehir, Turkey, 26040
Sponsors and Collaborators
Eskisehir Osmangazi University
  More Information Identifier: NCT01091402     History of Changes
Other Study ID Numbers: 1
Study First Received: March 23, 2010
Last Updated: March 23, 2010

Keywords provided by Eskisehir Osmangazi University:
autologous serum skin test, IL-18

Additional relevant MeSH terms:
Skin Diseases, Vascular
Skin Diseases
Hypersensitivity, Immediate
Immune System Diseases processed this record on May 25, 2017