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Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading

This study has been completed.
The Danish Rheumatism Association
Danish Ministry of Health, Internal Affairs
Danish National Research Council
The Danish Medical Research Council
Information provided by:
Bispebjerg Hospital Identifier:
First received: March 18, 2010
Last updated: NA
Last verified: March 2010
History: No changes posted
In the present study the microdialysis method is used to investigate biochemical changes within and around the joint simultaneously in both the resting state and in a joint that had been subjected to exercise. The aim of the present study was, by applying the microdialysis technique, to monitor markers of cartilage breakdown and inflammation in 2 different positions of the knee (inside and in the inner part of the knee capsule) in a group of human females with knee osteoarthritis over a period of 3 hours.

Condition Intervention Phase
Osteoarthritis Exercise Other: Exercise Other: Non Exercise Early Phase 1

Study Type: Interventional
Study Design: Intervention Model: Parallel Assignment
Primary Purpose: Basic Science

Resource links provided by NLM:

Further study details as provided by Bispebjerg Hospital:

Study Start Date: August 2008
Primary Completion Date: March 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Exercise Other: Exercise
Placebo Comparator: Non Exercise Other: Non Exercise


Ages Eligible for Study:   55 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   Female

Inclusion Criteria:

  • verified osteoarthritis (x-ray)of the knee, female,

Exclusion Criteria:

  • dementia, inflammatory diseases, regular pain medication
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No Contacts or Locations Provided
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT01090375     History of Changes
Other Study ID Numbers: H-KF-306126
Study First Received: March 18, 2010
Last Updated: March 18, 2010

Keywords provided by Bispebjerg Hospital:
biochemical markers

Additional relevant MeSH terms:
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases processed this record on June 23, 2017