ClinicalTrials.gov
ClinicalTrials.gov Menu

Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01090375
Recruitment Status : Completed
First Posted : March 19, 2010
Last Update Posted : March 19, 2010
Sponsor:
Collaborators:
The Danish Rheumatism Association
Danish Ministry of Health, Internal Affairs
Danish National Research Council
The Danish Medical Research Council
Information provided by:
Bispebjerg Hospital

Brief Summary:
In the present study the microdialysis method is used to investigate biochemical changes within and around the joint simultaneously in both the resting state and in a joint that had been subjected to exercise. The aim of the present study was, by applying the microdialysis technique, to monitor markers of cartilage breakdown and inflammation in 2 different positions of the knee (inside and in the inner part of the knee capsule) in a group of human females with knee osteoarthritis over a period of 3 hours.

Condition or disease Intervention/treatment Phase
Osteoarthritis Exercise Other: Exercise Other: Non Exercise Early Phase 1

Study Type : Interventional  (Clinical Trial)
Intervention Model: Parallel Assignment
Primary Purpose: Basic Science
Study Start Date : August 2008
Actual Primary Completion Date : March 2009

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arm Intervention/treatment
Experimental: Exercise Other: Exercise
Placebo Comparator: Non Exercise Other: Non Exercise




Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   55 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   Female
Criteria

Inclusion Criteria:

  • verified osteoarthritis (x-ray)of the knee, female,

Exclusion Criteria:

  • dementia, inflammatory diseases, regular pain medication

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT01090375     History of Changes
Other Study ID Numbers: H-KF-306126
First Posted: March 19, 2010    Key Record Dates
Last Update Posted: March 19, 2010
Last Verified: March 2010

Keywords provided by Bispebjerg Hospital:
osteoarthritis
biochemical markers
cartilage
inflammation
microdialysis

Additional relevant MeSH terms:
Osteoarthritis
Arthritis
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases