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Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01090375
First Posted: March 19, 2010
Last Update Posted: March 19, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
The Danish Rheumatism Association
Danish Ministry of Health, Internal Affairs
Danish National Research Council
The Danish Medical Research Council
Information provided by:
Bispebjerg Hospital
  Purpose
In the present study the microdialysis method is used to investigate biochemical changes within and around the joint simultaneously in both the resting state and in a joint that had been subjected to exercise. The aim of the present study was, by applying the microdialysis technique, to monitor markers of cartilage breakdown and inflammation in 2 different positions of the knee (inside and in the inner part of the knee capsule) in a group of human females with knee osteoarthritis over a period of 3 hours.

Condition Intervention Phase
Osteoarthritis Exercise Other: Exercise Other: Non Exercise Early Phase 1

Study Type: Interventional
Study Design: Intervention Model: Parallel Assignment
Primary Purpose: Basic Science

Resource links provided by NLM:


Further study details as provided by Bispebjerg Hospital:

Study Start Date: August 2008
Primary Completion Date: March 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Exercise Other: Exercise
Placebo Comparator: Non Exercise Other: Non Exercise

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   55 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   Female
Criteria

Inclusion Criteria:

  • verified osteoarthritis (x-ray)of the knee, female,

Exclusion Criteria:

  • dementia, inflammatory diseases, regular pain medication
  Contacts and Locations
No Contacts or Locations Provided
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT01090375     History of Changes
Other Study ID Numbers: H-KF-306126
First Submitted: March 18, 2010
First Posted: March 19, 2010
Last Update Posted: March 19, 2010
Last Verified: March 2010

Keywords provided by Bispebjerg Hospital:
osteoarthritis
biochemical markers
cartilage
inflammation
microdialysis

Additional relevant MeSH terms:
Osteoarthritis
Arthritis
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases