The Effectiveness of 18F-fluorocholine Positron Emission Tomography (PET) in Detecting, Staging and Following-up Prostate Cancer
|ClinicalTrials.gov Identifier: NCT01089881|
Recruitment Status : Unknown
Verified March 2010 by National Taiwan University Hospital.
Recruitment status was: Recruiting
First Posted : March 19, 2010
Last Update Posted : March 19, 2010
|Condition or disease|
Prostate cancer is a leading cause of cancer death for male in Taiwan. Although 18F-FDG PET has been shown to be an effective tool in diagnosing many malignancies, previous studies have shown that 18F-FDG is not a suitable PET tracer for detecting prostate cancer. Choline is one of the components of phosphatidylcholine, an essential element of phospholipids in the cell membrane. Some malignant cells show their ability to actively incorporate choline to produce phosphocholine and phosphatidylcholine to facilitate tumor cell duplication. The efficacy of 18F-fluorocholine (18F-FCH) for localizing primary or metastatic prostate cancer has been recently reported in limited studies.
This study will be conducted to delineate the effectiveness of 18F-FCH PET in (1) differentiating benign prostate hypertrophy (BPH) from prostate cancer, (2) staging prostate cancer, (3) following-up patients with prostate cancer after initial curative therapy.
Patients and Methods:
This study will include
- Group 1: 50 patients with BPH
- Group 2: 50 patients with newly diagnosed prostate cancer and
- Group 3: 50 patients who have received curative treatment for prostate cancer and are suspicious of recurrence/metastases because of a persistent increase in their serum PSA.
18F-FCH whole-body PET will be performed for each patient
To evaluate the effectiveness of 18F-FCH in the diagnosis, staging and follow-up of prostate cancer.
|Study Type :||Observational|
|Estimated Enrollment :||150 participants|
|Official Title:||The Effectiveness of 18F-fluorocholine PET in Detecting, Staging and Following-up Prostate Cancer|
|Study Start Date :||January 2008|
|Estimated Primary Completion Date :||December 2010|
|Estimated Study Completion Date :||December 2010|
patients with BPH
patients with newly diagnosed prostate cancer
patients who have received curative treatment for prostate cancer and are suspicious of recurrence/metastases because of a persistent increase in their serum PSA.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01089881
|Contact: Yu-Hong Jeng, M.D.||886-2-23123456 ext 62134||Yhj5251@ntu.edu.tw|
|National Taiwan University Hospital||Recruiting|
|Taipei,, Taiwan, 10043|
|Contact: Yu-Hong Jeng, M.D. 886-2-23123456 ext 62134 Yhj5251@ntu.edu.tw|
|Principal Investigator:||Yu Hong Jeng, M.D||National Taiwan University Hospital|